About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Iron-eliminating Protein may Play an Important Role in the Treatment of Breast Cancer

by Savitha C Muppala on August 5, 2010 at 3:39 PM
Font : A-A+

Iron-eliminating Protein may Play an Important Role in the Treatment of Breast Cancer

A protein which removes iron from cells may help slow the growth of cancerous tumors and treat breast cancer.

Researchers at Wake Forest University Baptist Medical Center in North Carolina found that levels of ferroportin -- a protein that exports iron from cells -- are strikingly lower in breast tumors than in normal tissue.

Advertisement

The lack of ferroportin results in a build-up of iron, which allows a tumor to grow and perhaps become more aggressive, Suzy Torti, an associate professor of biochemistry at Wake Forest Baptist and one of the lead investigators on the study published in Science Translational Medicine, said.

When the researchers restored ferroportin levels to normal in human breast tumors in mice, the tumors grew more slowly.

"Because ferroportin can remove iron from the cell, when we put the protein back into the cell, the ferroportin removed the cancer's growth stimulus," said Torti.
Advertisement

"Our findings suggest that ferroportin is a substantial influence on the behavior of the cancer," she said.

Patients should not, however, change the amount of iron in their diets, she stressed, because the study was focused on cellular, not dietary iron.

The researchers also looked at data on more than 800 women with breast cancer to see if they could find a link between ferroportin levels and long-term outcomes for cancer.

They found that low ferroportin levels were a strong predictor of a poor outcome for women with breast cancer and that ferroportin levels were lowest in the most aggressive areas of cancer.

But they also had good news: high levels of ferroportin predicted a 90-percent chance that a woman would be a long-term cancer survivor.

"Using ferroportin as a marker for iron regulation may be a useful tool in breast cancer prognosis and may even help direct therapy," the study said.

"In the future, manipulating levels of ferroportin or proteins that affect levels of ferroportin may prove to be an effective breast cancer treatment," it said.

Source: AFP
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Ways to Manage Stress during COVID-19 Pandemic
Can Adjusting Fatty Acid Intake Improve Mood in Bipolar Disorder Patients?
Insulin Resistance Doubles the Risk of Major Depressive Disorder
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Women and Cancer Pagets disease of the breast Mastitis Cancer and Homeopathy Breast Cancer Facts Cancer Facts Cancer Tattoos A Body Art Breasts - Structures and Types Breast Lumps 

Recommended Reading
Breast Cancer during Pregnancy
Management of breast cancer during pregnancy or pregnancy associated breast cancer requires special ...
Women and Cancer
Cancer is one of the frequently talked about and most feared disease that falls under the genre of ....
Breast Lumps
Most breast lumps are caused by hormonal changes in a woman and may not be cancerous. Common causes ...
Breasts - Structures and Types
Different stages of breast development in women and an in-depth look at the breast/bust and its ......
Mastitis
Mastitis is a common cause of tenderness, swelling and pain in breast, owing to inflammation in the ...
Pagets disease of the breast
A detailed description of the Paget's disease of the breast, characteristic signs and symptoms, dete...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use