In mice, a drug that appears to target specific intestinal bacteria in the guts may create a chain reaction that could eventually lead to new treatments for obesity and diabetes in humans.
This is according to a team of researchers. Mice fed a high-fat diet and provided tempol, an anti-oxidant drug that may help protect people from the effects of radiation, were significantly less obese than those that did not receive the drug, according to Andrew Patterson, assistant professor of molecular toxicology, Penn State, who worked with Frank J. Gonzalez, laboratory metabolism chief, and James B. Mitchell, radiation biology branch chief, both of the National Cancer Institute.
Link Between Retail Investment and Teen Obesity Explored
A new study suggests that communities should look at the greater retail environment of each neighborhood.
Advertisement
"The two interesting findings are that the mice that received tempol didn't gain as much weight and the tempol somehow impacted the gut microbiome of these mice," said Patterson. "Eventually, we hope that this can lead to a new line of therapeutics to treat obesity and diabetes."The microbiome is the biological environment of microorganisms within the human body.
The researchers, who reported their findings in the current issue of Nature Communications, said that tempol reduces some members of a bacteria -- a genus of Lactobacillus -- in the guts of mice. When the Lactobacillus levels decreases, a bile acid -- tauro-beta-muricholic acid -- increases.
![Carbohydrates and Its Role in Obesity]( "Carbohydrates and Its Role in Obesity")
Over 1 billion people world-wide are obese thus affecting their health due to their nutrition and lifestyle. 3.9% of India's population is obese! Know more about obesity and its prevention.
This inhibits FXR -- farnesoid X receptor, which regulates the metabolism of bile acids, fats and glucose in the body, according to the researchers."The study suggests that inhibiting FXR in the intestine might be a potential target for anti-obesity drugs," said Gonzalez.
The researchers said that tempol may help treat type 2 diabetes symptoms.
Source: Eurekalert
Carbohydrates and Its Role in Obesity
Over 1 billion people world-wide are obese thus affecting their health due to their nutrition and lifestyle. 3.9% of India's population is obese! Know more about obesity and its prevention.
Advertisement
This inhibits FXR -- farnesoid X receptor, which regulates the metabolism of bile acids, fats and glucose in the body, according to the researchers."The study suggests that inhibiting FXR in the intestine might be a potential target for anti-obesity drugs," said Gonzalez.
The researchers said that tempol may help treat type 2 diabetes symptoms.
Source: Eurekalert
Combination of Smoking and Obesity is Very Dangerous
A new study has found that the combination of obesity and smoking could lead to more health problems compared to both factors separately.
Advertisement
 Research Links Obesity and the Body's Production of FructoseResearchers report that the cause of obesity and insulin resistance may be tied to the fructose your body makes in addition to the fructose you eat. | Advertisement
|
Advertisement
Recommended Reading
Latest Research News
New study findings delineate how aging affects the immune response following Spinal cord injury (SCI) and highlight the participation of the spinal cord meninges in repair.
A recent clinical trial suggests that the first medication therapy to reduce the progression of nearsightedness in children could be on the way.
Autoimmune disorders were found to be linked to Sjogren's, systemic lupus erythematosus, and systemic sclerosis.
Successful brain pacemaker implantation has helped a 51year old Parkinson's disease patient to revitalize her quality of life.
Recent recommendations on lifestyle behaviors to prevent progression of rheumatic and musculoskeletal diseases revealed.