Among patients with high blood pressure, intensive blood pressure control was linked to a smaller increase in brain white matter lesions (a marker of small vessel disease and a risk factor for dementia) compared to standard blood pressure control, although the difference was small.
Hypertension is a risk factor for developing white matter lesions. This analysis is a substudy of a randomized clinical of 449 patients with high blood pressure who had initial brain magnetic resonance imaging (MRI) and a follow-up MRI after four years.
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‘Intensive systolic blood pressure control (goal of less than 120 mm Hg) was associated with a smaller increase in white matter lesion volume compared with standard treatment (goal of less than 140 mm Hg). ’
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Researchers report intensive systolic blood pressure control (goal of less than 120 mm Hg) was associated with a smaller increase in white matter lesion volume compared with standard treatment (goal of less than 140 mm Hg).
There also was a greater decrease in total brain volume, although the difference was small and the significance of this finding is unclear.
Limitations of the study include the relatively short duration of the intervention and follow-up. Given the limited size of this study, it's also not possible to correlate changes in brain structure with dementia occurrence.
![Quiz on Blood Pressure]( "Quiz on Blood Pressure")
Blood pressure is an important vital sign. Answer this Quiz and learn more about blood pressure.
Authors: R. Nick Bryan, M.D., Ph.D., University of Texas at Austin, and coauthors (doi:10.1001/jama.2019.10551)
Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.
Source: Eurekalert
Limitations of the study include the relatively short duration of the intervention and follow-up. Given the limited size of this study, it's also not possible to correlate changes in brain structure with dementia occurrence.
Quiz on Blood Pressure
Blood pressure is an important vital sign. Answer this Quiz and learn more about blood pressure.
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Authors: R. Nick Bryan, M.D., Ph.D., University of Texas at Austin, and coauthors (doi:10.1001/jama.2019.10551)
Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.
Source: Eurekalert
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 Greater Blood Pressure Control can Help Protect Brain HealthControlling blood pressure can avert the dangers of age-related brain damage such as dementia and cognitive impairment, finds a new study. | Advertisement
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