Paget's disease is a common
skeletal disorder that can lead to bone deformity, fractures,
osteoarthritis, and bone pain. In a study of patients with Paget's disease of bone, long-term intensive bisphosphonate
therapy conferred no clinical benefit over giving bisphosphonates only
when patients felt bone pain.
Also, long-term bisphosphonate therapy was linked with a non-significant increase in the risk of fractures and serious adverse events.
Although bisphosphonates are effective at suppressing the elevated bone turnover and bone pain that are characteristic of Paget's disease of bone, the study's results suggest that the drugs should be used to control symptoms rather than to suppress bone turnover.