Our understanding of how myeloid derived suppressor cells (MDSCs) modulate the immune response to
viral infections is still very limited.
Myeloid derived suppressor cells (MDSCs), produced in the bone marrow as part of the human immune response to a tumor, may have a potent immunoregulatory role following viral infection.
The similarities and differences between tumor-induced versus virus-induced MDSCs and the potential to use these cells for targeted immunotherapies are discussed in a review article in Viral Immunology, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.
The authors discuss the mechanisms of MDSC immune suppression, the types of cells targeted, and the ability of MDSCs to directly alter the viral infectious process. They also report on the challenges in studying MDSC-mediated immunoregulation and the potential for developing antiviral therapies based on MDSC targeting.
"This review highlights the current state of knowledge regarding these important cells and considers how they might be harnessed therapeutically to attain a better balance of antiviral immunity and immunopathology," says David L. Woodland, Editor-in Chief of Viral Immunology and Chief Scientific officer for Keystone Symposia on Molecular and Cellular Biology.