Our understanding of how myeloid derived suppressor cells (MDSCs) modulate the immune response to
viral infections is still very limited.
Myeloid derived suppressor cells (MDSCs), produced in the bone marrow
as part of the human immune response to a tumor, may have a potent
immunoregulatory role following viral infection.
‘The current state of knowledge regarding myeloid derived suppressor cells and how they might be harnessed therapeutically to attain a better balance of antiviral immunity have been highlighted in the study.’
The similarities and
differences between tumor-induced versus virus-induced MDSCs and the
potential to use these cells for targeted immunotherapies are discussed
in a review article in Viral Immunology
, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.
In "The Role of Myeloid-Derived Suppressor Cells in Viral Infection,"
Megan O'Connor, Jessica Rastad, and William Green, Geisel School of
Medicine at Dartmouth, Lebanon, NH, describe the MDSCs and MDSC-like
cells found during viral infection.
The authors discuss the mechanisms
of MDSC immune suppression, the types of cells targeted, and the ability
of MDSCs to directly alter the viral infectious process. They also
report on the challenges in studying MDSC-mediated immunoregulation and
the potential for developing antiviral therapies based on MDSC
"This review highlights the
current state of knowledge regarding these important cells and considers
how they might be harnessed therapeutically to attain a better balance
of antiviral immunity and immunopathology," says David L. Woodland, Editor-in Chief of Viral Immunology
and Chief Scientific officer for Keystone Symposia on Molecular and Cellular Biology.