About Careers MedBlog Contact us

Insights into How Dendritic Cells Teach Tolerance to T Cells

by Dr. Trupti Shirole on October 29, 2016 at 6:32 AM
Font : A-A+

 Insights into How Dendritic Cells Teach Tolerance to T Cells

The immune system maintains health by avoiding the dangers of over- and under-responses. People with immune systems that do not efficiently fight off pathogens, like viruses or bacteria, will become sick. On the other hand, an immune system that is too robust may develop autoimmune diseases.

In research published in the prestigious journal Immunity, a Saint Louis University researcher reports new findings that help understand how the immune system's dendritic cells direct other immune cells called T lymphocytes to continue to learn tolerance for the body's own cells.


Daniel Hawiger, associate professor of molecular microbiology and immunology at SLU, studies a type of immune cell called dendritic cells which serve as the conductors of the immune system's symphony.

"They are the music directors, telling other lymphocytes such as T cells what to do and how to do it. Their most important role is to govern immune responses. T cells are the immune system's fighters," Hawiger said. "Dendritic cells help train T cells to distinguish between self and non-self."

During an infection, dendritic cells direct a battle hymn telling T cells which entities are pathogens and instructing the T cells to fight them off.

At other moments, they direct a lullaby, instructing T cells not to fight. Dendritic cells teach self-reactive T cells to leave the body's own cells and proteins unharmed, creating tolerance toward self.

Usually dendritic cells make the correct decision, playing a rousing call-to-arms or soothing melody, as appropriate.

Sometimes, however, dendritic cells fail to appropriately down-regulate the immune response. On the other hand, an indiscriminate tolerance induced by dendritic cells could cause a problem by unnecessarily dampening the immune response.

While scientists understood the role of dendritic cells, the way in which they accomplish this remained unclear.

Hawiger wanted to learn more about how dendritic cells teach tolerance to T cells.

In research published last year, Hawiger and his team discovered a previously unknown mechanism that the T cells use to maintain tolerance.

With the current study, they've built on that finding to discover more about how this T cell mechanism is governed by the functions of specialized dendritic cells. Specifically, the team reports two key findings.

First, in contrast to what was previously believed, the presentation of antigens to T cells by all dendritic cells under non-infection, non-inflammation conditions does not lead to the induction of tolerance. It also does not lead to immunity. Rather, it causes short term activation of T cells but no long term effects.

Second, the researchers discovered that tolerance can be induced only when antigens are acquired and then presented to T cells by a specialized group of dendritic cells that give specific signals to T cells. It is only under these special circumstances, using the mechanisms that Hawiger's team identified, that tolerance occurs.

This improved understanding of how the immune system works offers a chance to develop new ways to control the body's immune response.

"I hope this new information may help us more precisely regulate the immune response," Hawiger said. "In the case of an illness like multiple sclerosis, where the immune response is causing damage, we may be able to develop a therapy that will dampen that response.

"Perhaps we can harness these functions and learn to turn the volume up or down, in response to the needs of those with a variety of health concerns, and in particular, autoimmune diseases."

Source: Eurekalert

News A-Z
What's New on Medindia
Diet and Oral Health: The Sugary Connection May Become Sour
World AIDS Day 2022 - Equalize!
Test Your Knowledge on Sugar Intake and Oral Health
View all
News Archive
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Surgical Treatment 

Most Popular on Medindia

Loram (2 mg) (Lorazepam) Drug Side Effects Calculator Blood Pressure Calculator Blood Donation - Recipients Drug - Food Interactions Post-Nasal Drip Sinopril (2mg) (Lacidipine) Calculate Ideal Weight for Infants Find a Doctor How to Reduce School Bag Weight - Simple Tips
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Insights into How Dendritic Cells Teach Tolerance to T Cells Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests