About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Innovative Approach for Killing HIV Virus

by Savitha C Muppala on August 21, 2010 at 6:25 PM
Font : A-A+

 Innovative Approach for Killing HIV Virus

A novel approach to eliminate HIV in the host by destroying only the infected cells is an idea being explored by scientists and if this is a success can lead to an effective anti-HIV therapy.

Current HIV treatments do not eradicate HIV from host cells but rather inhibit virus replication and delay the onset of AIDS.

Advertisement

On infection, HIV spreads through the human body after the viral DNA is incorporated into the genome of host cells.

Highly Active Anti-Retroviral Therapy (HAART) works by blocking HIV replication at various steps but does not eliminate the infected cells.

Professors Abraham Loyter, Assaf Friedler and their colleagues at Hebrew University, Jerusalem, focussed on the elimination of infected cells.
Advertisement

Loyter contends that while HIV integrates its DNA into the human genome, it only inserts enough DNA to replicate yet avoids host genome instability leading to programmed death of the infected cells (apoptosis).

The researchers sought to induce increased integration of HIV DNA into human genome that could lead to apoptosis.

Toward that goal, they developed peptides (called "mix") that can penetrate into infected cells and stimulate the activity of the viral integrase.

The stimulation of the viral integrase resulted in an increase in the number of the viral DNA molecules integrated into the infected cells that lead the infected cells into "panic mode", causing self-destruction.

"Whilst this research is promising, a major caveat with these studies is that they are preliminary. So far these experiments have only been shown to 'cure' HIV from small dishes of cultured cells in the authors' laboratory, but the findings are an exciting development in the quest to eradicate this devastating global pandemic," said Loyter.

The study is published in BioMed Central's open access journal, AIDS Research n Therapy.

Source: ANI
Advertisement
Advertisement
Advertisement

Recommended Reading

This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Innovative Approach for Killing HIV Virus Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests