Injectable for Quick Healing of Fractures Soon to Enter clinical Trial

New injection drug named NOV004 from Novosteo Inc., helps to heal fractures quickly. It is unique that it concentrates at the fracture site while reducing exposure to the rest of the body.

Novosteo, the startup developing the drug, was co-founded by father-son team Philip S. Low, the Presidential Scholar for Drug Discovery and the Ralph C. Corley Distinguished Professor of Chemistry, and Stewart A. Low, the company's CSO and Visiting Scholar in Purdue's Department of Chemistry.

Compound Fractures | Open Fractures - Symptoms, Diagnosis,Treatment
Compound Fracture is an injury that occurs when a fracture directly communicates with the external environment through an open wound. Compound fractures are also called open fractures.

‘New injectable drug is targeted to heal broken bones faster and strengthen weak bones. It has completed preclinical studies and it has to enter clinical trials this year.’
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The treatment was developed in the Purdue laboratory of Low in the Purdue Institute of Drug Discovery. Currently there are 288 clinical trials performed or in process using Purdue-developed medical treatments at 4,841 sites across the globe.

Scott Salka, who recently joined the startup as executive chair, will use his 28 years of experience as a biotechnology entrepreneur to help Novosteo move its innovations from the laboratory to clinical trials and ultimately in to the hands of doctors and patients.

"We have been working on some amazing science with people truly dedicated to making a difference in reducing the mortality and improving the quality of life for our aging population," said Salka. "We have completed preclinical studies with NOV004 and are looking to take it to clinical trials later this year."

As CEO, Salka has successfully led efforts to advance novel drugs through preclinical and early clinical development, most recently at publicly traded Ampliphi, now Armata NYSE: ARMP. Prior to that he founded and served as CEO for both Ambit Biosciences, acquired by Daiichi Sankyo OTC: DSNKY, and Rakuten Medical.

Novosteo is already looking at the future use of the injectable-targeted drug for other applications, including dental implants, head and facial fractures, and hip and knee replacements. In addition, Novosteo has a pipeline of drugs for treating an array of musculoskeletal maladies. Salka will present some of the technology at Biocom's Global Life Science Partnering Conference this month in La Jolla, California.

Novosteo's technology is licensed through the Purdue Research Foundation Office of Technology Commercialization.

The company also received entrepreneurial support from Purdue Foundry, an entrepreneurship and commercialization hub in Discovery Park District's Convergence Center for Innovation and Collaboration where startups, entrepreneurs, innovators and companies can collaborate with Purdue to address global challenges in health, sustainability, IT and space.

The Purdue Institute of Drug Discovery is situated near the district, a $1 billion-plus long-term enterprise to support a transformational center of innovation on the western edge of the Purdue University campus.

The district already includes a public airport with a 7,000-foot runway, and partnerships international companies including Rolls-Royce, Schweitzer Engineering Laboratories and Saab. Visit Discovery Park District.

Source-Eurekalert