Inhibition of Breath by Stimulation of Human Amygdala Gives a Key Insight Into SUDEP

Sudden unexpected death in epilepsy (SUDEP) is recognized as a very real and devastating problem in which breathing impairment is believed to play a critical role.Researchers from University of Iowa have identified areas of the human brain where breathing is controlled or in some cases, impaired by activating the amygdala using electrical stimulation. This actually provides an important insight into SUDEP.

Using a research participant with medically intractable epilepsy (which can't be controlled with two or more medications) and whose brain was already being monitored to map the focus of seizures, researchers found that when seizures spread to the amygdala, the patient stopped breathing. That effect could be reproduced by electrically stimulating the amygdala. Strikingly, the patient wasn't aware he wasn't breathing even though he was wide awake at the time. This finding was reproduced in two other human subjects.

"Amazingly, the patient was completely unaware that he had stopped breathing," says Dr.Brian Dlouhy, assistant professor of neurosurgery at UI Carver College of Medicine and lead author of the study. "It was remarkable to all of us that one of the essentials of life - breathing - could be inhibited and the patients themselves were completely unaware of this."

“The patient just sat there, unconcerned that he was not breathing," says John Wemmie, professor of psychiatry, molecular physiology and biophysics, and neurosurgery at the UI Carver College of medicine, and an author of the paper. "If we asked him to hold his breath for the same duration of time, it was difficult for him and he could barely do it. But when the amygdala was stimulated, he didn't even notice that his breathing had stopped."

Dr. George Richerson, professor and chairman of neurology, and professor of molecular physiology, biophysics and neurosurgery at the UI Carver College of Medicine, also an author on the paper, says, "These findings provide an explanation for why SUDEP occurs after seizures, because patients would stop breathing but be completely unaware that their blood oxygen levels are progressively dropping to fatally low levels. The lack of awareness would prevent activation of the reflex that is needed to restore oxygen levels back to normal."

Dlouhy says, "Identifying brain areas where seizure spread interferes with breathing may help identify patients at risk for SUDEP and lead to preventive strategies.”

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Source-Eurekalert