Localizing of the multifunctional enzyme 3β-Hydroxysteroid-Δ24 reductase (DHCR24) to the endoplasmic reticulum has neuroprotective and cholesterol-synthesizing abilities. DHCR24 overexpression confers neuroprotection against apoptosis caused by amyloid β deposition.
Dr. Xiuli Lu and colleagues from Liaoning University in China constructed two recombinant adenoviruses (Ad-rSYN1-DHCR24-myc and Ad-hSYN1-DHCR24-myc) that drive DHCR24 expression specifically in neuronal cells. They also found that adenovirus transfection inhibits apoptosis through scavenging excess reactive oxygen species. In summary, these researchers have for the first time successfully constructed an adenovirus that induces DHCR24 specifically in neuronal cells. These findings published in the Neural Regeneration Research (Vol. 9, No. 5, 2014) will lay the foundation for further studies on DHCR24 gene therapy and neuronal functional research in animal models.
Cardiac Markers
Cardiac markers are biomarkers which are measured to evaluate the function of heart. The test for troponin may be regarded as the most sensitive and specific test for myocardial
Source: Eurekalert
CoQ10
Vitamin-like CoQ10 helps generate energy for the cells to function at their optimum level. Secondary to its role in energy production, CoQ10 also functions as a potent antioxidant.
Liver Enzymes can Predict Pre-diabetes and DiabetesAn increase in liver enzymes and fatty liver is associated with pre-diabetes and diabetes. | Advertisement
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High Doses of Statins Better for Regression of Heart Disease
Intensive statin treatment led to coronary artery disease regression with few adverse events.High doses of rosuvastatin and atorvastatin reduced the amount of coronary artery plaques.
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