In autoimmune diseases, the immune system turns against the body instead of protecting it. Aicardi-Goutieres Syndrome (AGS) is a rare genetic disorder that mainly affects the brain, while systemic lupus erythematosus (SLE) can affect the skin, joints, kidneys, brain and other organs. Neither disease has a cure, and treatments can control symptoms. Researchers at the UT Southwestern Medical Center have identified an enzyme as a major culprit of these two autoimmune diseases. An enzyme, called cGAS, sounds an alarm for the body's innate immune system. The research team observed that activating this enzyme causes AGS and SLE in mice, while inhibiting the same enzyme rescues them. Senior author Dr. Zhijian James Chen said, "These results suggest that inhibition of the enzyme cGAS may be an effective therapy for autoimmune diseases such as AGS and SLE, which are linked to the same inflammatory pathway. cGAS is likely amenable to inhibition by small-molecule drugs and that the recent determination of the high-resolution structures of cGAS should facilitate development of such inhibitors." ‘Researchers at the UT Southwestern Medical Center have identified an enzyme as a major culprit of Aicardi-Goutieres Syndrome and systemic lupus erythematosus. Activating the cGAS enzyme causes AGS and SLE in mice, while inhibiting the same enzyme rescues them.’ The research team also studied mice genetically engineered to lack a DNA-digesting enzyme called DNase-II. The researchers said, "While the resulting inability to degrade lysosomal DNA led to lethal autoimmunity, once again cGAS inhibition rescued the mice." The study is published in the Proceedings of the National Academy of Sciences (PNAS).Source: ANI << Robotic Surgery is All About Better Vision, Precision, Cont... Indian-Origin Researcher Wins Grant to Study Deadly Skin Ca... >> Recommended Reading Study Reveals Gender Bias Found In Autoimmune Diseases Females can mount more powerful immune responses than males. Despite this, the flip side of this enhanced protection against infections is a greater risk for autoimmune disorders. READ MORE Do Autoimmune Diseases Affect Pregnancy? The occurrence of rheumatic diseases before or during pregnancy requires our much-needed attention as it has some significant impacts on the off springs. READ MORE Study Finds Out How Protein That Plays Key Role in Cancer and Autoimmune Diseases is Activated A new study has identified the process through which a complex protein that plays a crucial role in the development of cancer, viral infection and autoimmune diseases is activated. READ MORE Novel Discovery in Autoimmune Diseases, Cancer Researchers have made an important finding that paves way in understanding of how our immune system "learns" not to attack our won body. READ MORE Anal Warts Anal warts or genital warts are soft bumps caused by Human Papilloma Virus and are a sexually transmitted disease. Wart removal is done by surgical procedure or application of drugs. READ MORE Autoimmune Disorders Autoimmune disorders occur when the immune system fails to recognize the body as ‘self’ and attacks it. READ MORE Chemotherapy ‘Chemo’ means medicine or ‘drug’; ‘therapy’ means ‘treatment’. Chemotherapy refers to the use of cytotoxic drugs in cancer treatment. READ MORE Chemotherapy Drugs Chemotherapy drugs perform like ‘magic bullets’ to destroy cancer cells in the body. READ MORE Food Preservatives - How Safe Are They? Food preservatives are basically antimicrobials or anti-oxidants that help preserve food by destroying the microbes and stopping decomposition of food products. READ MORE Granulomatosis with Polyangiitis (GPA) Granulomatosis with Polyangiitis (GPA) is a type of vasculitis that usually affects the upper airways, lungs and kidneys. READ MORE Microscopic Polyangiitis Microscopic polyangitis, infection of small blood vessels, presents with general symptoms of fever, muscle pain and weight loss. Localized symptoms can also occur. READ MORE Myasthenia Gravis Myasthenia gravis is the commonest disorder of neuromuscular transmission. Autoimmune myasthenia gravis needs to be distinguished from congenital myasthenic syndromes. READ MORE Systemic Lupus Erythematosus Systemic Lupus Erythematosus (SLE) is an autoimmune disease that affects multiple organs like the joints, skin, kidney, heart, lungs, blood vessels and brain. READ MORE Vitiligo Vitiligo is a skin disease characterized by patches of unpigmented skin. Vitiligo is usually slowly progressive. Melanin is either destroyed or not produced. READ MORE Most Popular on Medindia Nutam (400mg) (Piracetam) Post-Nasal Drip A-Z Drug Brands in India More News on: Systemic Lupus ErythematosusChemotherapyChemotherapy DrugsAnal WartsMyasthenia GravisVitiligoAutoimmune DisordersGranulomatosis with Polyangiitis (GPA)Microscopic PolyangiitisFood Preservatives - How Safe Are They?