About My Health Careers Internship MedBlogs Contact us

Influenza Vaccine Elicits Acceptable Immunity in Ferrets

by Rajashri on October 30, 2008 at 4:42 PM
Font : A-A+

 Influenza Vaccine Elicits Acceptable Immunity in Ferrets

Researchers have revealed that a novel influenza vaccine, which is delivered nasally, has been found to trigger robust immunity in ferrets.

Experts at NanoBio Corporation have revealed that the immune responses elicited by the new vaccine were more than 20 times higher than those generated by two injections of the currently approved vaccines.


The researchers also revealed that their intranasal vaccine used only half the standard antigen dose to produce that effect.

According to them, their nasal vaccines exert adjuvant activity without the need for pro-inflammatory materials, toxins or cytokines.

"Our nanoemulsion-based intranasal vaccine adjuvant system represents a paradigm shift in vaccinology. It can be used to safely deliver multiple antigen types directly into the lining of the nasal mucosa, which is rich in dendritic cells that present the antigen(s) to the immune system," said James R. Baker, Jr., M.D., founder and chairman of NanoBio Corp.

"The nanoemulsion adjuvant uniquely interacts with these cells to trigger unparalleled mucosal and systemic immunity," he added.

During the study, the team gave ferrets 7.5, 15 and 45 micrograms of nanoemulsion-adjuvanted influenza vaccine, and found all three doses to produce antibody responses substantially higher than those triggered by the standard intramuscular vaccine.

The ferrets, which represented the most relevant influenza animal model for humans, were then challenged with live influenza virus, and all were protected.

"A large, unmet medical need still exists for protecting people from influenza infection. The robust immunity and antigen-sparing capability demonstrated in this study are especially important for addressing this unmet need, as are the demands for a vaccine that would protect people in the face of a flu pandemic," Baker said.

NanoBio plans to begin a phase 1 clinical study for seasonal influenza in the first half of 2009, and is currently initiating pre-clinical studies in pandemic flu.

The results of the study were presented at the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)/Infectious Diseases Society of America (IDSA) 46th annual meeting in Washington, D.C.

Source: ANI

News A-Z
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Hib Vaccine Immunisation Flu Swine Flu Myasthenia Gravis Reye’s Syndrome Blood Group Diet Preventing Flu: Good Health Habits Can Help Stop Germs Boils - Treatment by Drugs Top 10 Vaccine Myths Debunked 

Recommended Reading
Hepatitis B
Hepatitis B is inflammation of the liver due to infection with the hepatitis B virus....
Cholera is an infection of the small intestine and is caused by the bacterium Vibrio cholerae....
Study Says Vaccinating Family may Help Protect Newborns Against Flu
Vaccinating new mothers and other family members against influenza can protect newborns against the ...
GAVI Alliance Says Vaccination Programmes Avert 3.4 Million Deaths
Immunisation programmes against meningitis and hepatitis in the world's poorest countries will have ...
Blood Group Diet
What is right diet for you may be the wrong one for another. The diet that suits you will depend on ...
Boils - Treatment by Drugs
Diabetes patients have reduced immunity, which makes them more susceptible to skin infections like b...
Hib Vaccine
The Hib vaccine protects children against infections like meningitis and pneumonia that are caused b...
Myasthenia Gravis
Myasthenia gravis is the commonest disorder of neuromuscular transmission. Autoimmune myasthenia gra...
Preventing Flu: Good Health Habits Can Help Stop Germs
How is the flu spread and how effective is flu treatment? Learn more about the influenza virus and g...
Reye’s Syndrome
Reye's syndrome is a medical emergency chiefly affecting children and teenagers and is marked by the...
Swine Flu
Swine flu, a type of influenza caused by a new strain of the H1N1 Type A influenza virus has origina...
Top 10 Vaccine Myths Debunked
Childhood vaccination has saved many lives, yet lots more has to be done to increase awareness and e...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use