World Health Organization has designed influenza vaccination programs based on its peak time, but a new study shows that countries in the tropics and subtropics exhibit diverse patterns of seasonal flu activity, where they can be grouped into eight geographical zones to optimize vaccine formulation and delivery timing. The study was published in the open-access journal PLOS ONE by Siddhivinayak Hirve from the World Health Organization, Geneva, Switzerland, and colleagues.
Historically, flu vaccine programs have been designed around predictable peaks in infection seasonally observed in temperate climates. However, vaccine programs based on seasonality in temperate regions may not apply to the tropics where patterns in influenza activity are less well understood. The authors of the present study used FluNet, a global tool for influenza surveillance, to analyze national flu data from 138 countries in the tropics and subtropics, examining flu seasonality and identifying annual peaks in flu cases.
The authors found that flu activity patterns in the tropics and subtropics were much more complex than in the temperate northern and southern hemispheres. They were able to discern patterns in influenza activity for 70 countries and found most of these had one or two distinct peaks per year. Countries nearest to the equator often had year-round flu activity. Based on their findings, the researchers constructed eight zones of countries sharing similar flu patterns: two zones in America, two in Asia and four zones in Africa and the Middle East.