About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Inflammation and Infection can be of Grave Concern

by Bidita Debnath on March 25, 2013 at 11:02 PM
Font : A-A+

 Inflammation and Infection can be of Grave Concern

Infections can be deadly, as the news has shown time and again.

Periprothesthetic joint infection (PJI) is the infection of grave concern to the orthopedic community, especially in its growingly common antibiotic-resistant form. This all-too-common infection can be found deep inside the joint prosthesis following joint replacement surgery.

Advertisement

Javad Parvizi, MD and colleagues at the Rothman Institute at Jefferson have worked for years to find a solution to this sometimes deadly infection. Their most recent work has attempted to determine the optimal thresholds for two common biomarkers for systemic inflammation and infection. It will be presented on March 21, 2013, at 4:06 pm, McCormick Place, Room S105, at the American Academy of Orthopedic Surgeons (AAOS) annual meeting in Chicago.

In previous studies, it was determined that testing the blood for elevated levels of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), known biomarkers for systemic inflammation and infection, was an accurate test for determining the presence of an infection. But, the levels of ESR and CRP that should sound the infection alarm have been inconsistent, particularly in regard to a new, industry-wide agreed upon definition for PJI.
Advertisement

The team retrospectively reviewed 1,993 patients who underwent revision surgery for aseptic failure (1,095 hips, 594 knees) or PJI (112 hips, 192 knees) between 2000 and 2009. Patients with comorbidities that could elevate the serum inflammatory markers were disqualified from the study.

Analysis was performed to determine the optimal threshold and test characteristics for ESR and CRP in hips and knees separately. The study found that the real threshold for these tests is higher than previously thought. In addition, researchers found that there is a difference between the knee and hip with regard to the extent these inflammatory markers are elevated with PJI.

The study confirmed the utility of ESR and CRP as a combination test in PJI diagnosis in a large cohort at a single institution. "The findings suggest conventional thresholds for these inflammatory markers may need to be refined to improve their accuracy in diagnosing PJI," says Dr. Parvizi.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Menstrual Disorders
Coffee May Help You Fight Endometrial Cancer
Fermented Skin Care
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Flu Anti-Inflammatory Diet Inflammation Top Ten Foods That Trigger Inflammation 

Recommended Reading
Birth Defects - Infections
Birth defects are abnormalities, which occur before the birth of the baby and can be caused due to ....
Acute Ear Infection
Ear infection is very common in babies and young children. The type of ear discharge depends on the ...
Vesico-Ureteric Reflux Causing UTI in Children
Bacterial infection of urinary bladder can cause pain and burning sensation while passing urine. ......
Anti-Inflammatory Diet
Healthy foods as part of anti-inflammatory diet to fight inflammation are basic components of the Me...
Inflammation
Inflammation is the response of living tissue to injury due to a variety of causes that call upon ho...
Top Ten Foods That Trigger Inflammation
Foods like refined carbohydrates, sugar, certain types of fat, artificial food additives and alcohol...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)