About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Infections may Be Combated by Good Gut Bacteria

by Rajashri on October 3, 2008 at 5:03 PM
Font : A-A+

 Infections may Be Combated by Good Gut Bacteria

A new study says that the DNA of so-called "good bacteria," which normally thrives in the intestines, could help the human body in fighting infections.

The findings of the study, led by Yasmine Belkaid, Ph.D., and her colleagues in the Laboratory of Parasitic Diseases at the National Institute of Allergy and Infectious Diseases (NIAID), may help in developing oral therapies against infections or autoimmune diseases.

Advertisement

Usually, an individual has 300 to 500 species of beneficial bacteria, known as commensals, in their intestines. These bacteria are not harmful and, in fact, help an individual maintain his or her digestive health. Typically, the immune system does not attack gut commensals, even though they are bacteria.

"Within the body of a healthy adult, microbial cells vastly outnumber human cells. Research to understand these microbial communities is an exciting scientific frontier. Among many opportunities related to the so-called 'microbiome,' targeting beneficial bacteria may offer new avenues for therapy against infectious and immune-mediated diseases," said Anthony S. Fauci, MD, NIAID director.
Advertisement

However, the scientists still find it hard to explain how commensals protect against harmful bacteria, known as pathogens.

"Pathogens often behave similarly to gut commensals," said Belkaid.

It is required that the immune system must distinguish the good bugs from the bad ones, because the body needs commensals but also has to rid itself of disease-causing microbes,

One mechanism of protection is through the interaction between the commensals and certain immune cells in the intestines, which occurs through the binding of the commensals to receptors on the T cells known as Toll-like receptors (TLRs).

In healthy individuals, some intestinal T cells (known as Tregs) play a regulatory role, recognizing commensals and keeping the immune system from attacking them. However, during an infection, T cells shift into attack mode to fight the infection.

The researchers have described a novel way in which the Tregs are regulated to facilitate an immune response to a pathogen. They found that during an infection, the DNA of the body's beneficial bacteria binds to a specific receptor on the intestinal immune cells, called TLR9.

The binding of commensal DNA to TLR9 in the presence of a pathogen prevents the generation of Tregs in favour of the generation of protective T cells. These protective T cells can then clear the body of the invading pathogen.

As a result, the commensal DNA acts as a natural adjuvant by boosting the activity of T cells so they can destroy the invading pathogen.

"There is a balance of regulatory immune signals in the body. During an infection, we've found that commensals can break this balance in favor of an infection-fighting response," noted Belkaid.

While the immune system must react to invading pathogens to maintain health, an immune response to commensals can cause problems. For example, certain inflammatory bowel diseases, such as Crohn's disease, are thought to be caused in part by immune reactions against commensal bacteria.

Te knowledge of how commensals interact with the immune system opens up the possibility of using beneficial bacteria as targets for future oral therapies against infections or autoimmune diseases.

The study is published in the latest issue of the journal Immunity.

Source: ANI
RAS/SK
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
First Dose of COVID-19 Vaccines May Improve Mental Health
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Shigellosis Flu Probiotics - Support System for the Gut Leaky Gut Syndrome 

Recommended Reading
Hodgkins Lymphoma
Hodgkins lymphoma or Hodgkins disease has the distinction of being the first cancer to be cured by ....
Stem Cells - Cord Blood
Encyclopedia section of medindia gives general info about Cord Blood...
AIDS / HIV - Treatment
Encyclopedia section of medindia explains in brief about the treatment for AIDS/HIV...
Immune System's Double Role in Cancer
Some proteins of the immune system can promote tumor growth, according to a study by researchers at ...
Leaky Gut Syndrome
Leaky gut syndrome is a condition caused by increased intestinal permeability of the gut. It resembl...
Probiotics - Support System for the Gut
Probiotics are live microorganisms that resemble the “good bacteria” in our gut. Science is yet to f...
Shigellosis
Shigellosis or Bacillary Dysentery is a common cause of gastro-enteritis worldwide and can cause blo...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use