A new study published in the Journal of American Society of Nephrology reveals that higher levels of particular proteins in the blood could be a sign of a common kidney disease.
The findings could lead to better diagnosis and management of patients with the disease, called IgA nephropathy.
IgA nephropathy occurs when IgA1, a protein that helps the body fight certain infections, becomes modified and settles in the kidneys. This 'first hit'' of the disease is followed by a 'second hit'' when the patient''s immune system mounts an antibody response against these modified IgA1 molecules. Over time, these events can damage the kidneys, which subsequently leak blood and protein in the urine, and can lead to hypertension and kidney failure.
"This paper is a first step, and in the future we have to refine these tests to check the impact of different treatments on these serum biomarkers, and to imagine new therapies with direct impacts on modified IgA1 or on the specific antibody responses against it," said Dr. Berthoux.
Study co-authors include Lise Thibaudin, MD, Nicolas Maillard, MD, PhD, Christophe Mariat, MD, PhD (University Hospital of Saint-Etienne, France); Hiroyuki Yanagawa MD, PhD; Yasuhiko Tomino, MD, PhD (Juntendo University, in Tokyo, Japan); and Bruce Julian, MD, PhD (University of Alabama at Birmingham).
Disclosures: The authors reported no financial disclosures.
The article, entitled " Autoantibodies targeting galactose-deficient IgA1 associate with progression of IgA nephropathy," will appear online at http://jasn.asnjournals.org/ on August 16, 2012, doi: 10.1681/ASN.2012010053.
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