A significant positive association between long sleep duration and the development of colorectal cancer, especially among persons who are overweight or snore regularly is reported in a new study. The results raise the possibility that obstructive sleep apnea may contribute to cancer risk.
"Our current study adds to the very limited literature regarding the relationship between sleep duration and/or sleep quality and colorectal cancer risk," said lead author Xuehong Zhang, MD, ScD, instructor in the Department of Medicine at Harvard Medical School and associate epidemiologist at Brigham and Women's Hospital in Boston. "The novel observation of increased risk among regular snorers who sleep long raises the possibility that sleep apnea and its attendant intermittent hypoxemia may contribute to cancer risk."
The study, which appears in the May issue of the journal Sleep, utilized data from two prospective cohort studies, the Health Professionals Follow-up Study (HPFS) and the Nurses' Health Study (NHS). A biennial questionnaire is sent to participants in each cohort to collect information on demographics, lifestyle factors and disease endpoints. Participants estimated their total hours of sleep in a 24-hour period and were asked if they snore.
The American Academy of Sleep Medicine reports that individual sleep needs vary. However, the general recommendation is that most adults should get about seven to eight hours of nightly sleep.
The authors suggest that the association between the self-reported long sleep duration and incident colorectal cancer may be explained by obstructive sleep apnea, which involves repetitive episodes of complete or partial upper airway obstruction occurring during sleep despite an ongoing effort to breathe. The major predisposing factor for obstructive sleep apnea (OSA) is excess body weight, and loud snoring is a common symptom of sleep apnea.
According to the authors, sleep disruption caused by OSA may reduce sleep quality and increase sleepiness, resulting in longer reported sleep durations. Furthermore, intermittent hypoxemia similar to that which occurs in OSA has been shown in animal models to promote tumor growth.
"Future studies should focus on different populations and evaluate to see whether sleep duration and sleep quality is a novel risk factor for colorectal cancer and to understand the mechanisms behind this association," said Zhang.
According to the Centers for Disease Control and Prevention (CDC), colorectal cancer is the third most commonly diagnosed cancer and the second leading cause of cancer deaths in men and women combined in the U.S.