About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Inactivation of One Protein can Lead to Colon Cancer

by Rishika Gupta on April 3, 2018 at 1:10 PM
Font : A-A+

 Inactivation of One Protein can Lead to Colon Cancer

APC protein's new role in inactivating colorectal cancer has been explored in the study. It also deals with the question of its inactivation and how it can trigger the development of a vast majority (80%) of all colorectal cancers. The findings of this study are published in the journal of Developmental Cell.

The researchers have identified a new function for this colon cancer gene: APC stops several colon cancer activators.

Advertisement


APC works in a pathway that allows one cell to communicate with its neighbors. When APC is inactivated, this pathway goes into overdrive, and that triggers colon cancer development. Exactly how APC acts in this pathway has remained a mystery.

The long-held view was that the sole function of APC is to cause the destruction of one activator of the overdrive activity. "The surprise from our research is that APC actually has a second role in putting the brakes on several other activators in the pathway," says Ahmed. "This work changes our view of how this key gene acts, revealing that APC's role is much broader and multi-faceted."
Advertisement

The team's work, "APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway" has been published as a feature article in Developmental Cell.

This new finding about the way that APC blocks the development of colorectal cancer may lead to new therapeutic targets to combat this disease. "Because this new role of APC involves proteins on the cell surface, targeting colorectal cancers may become easier," says Ahmed. "For example, therapeutic antibodies, which normally cannot work inside the cell, can now be used to treat colorectal cancers that have APC mutations."

Figuring out the exact way in which APC stops colon cancer activator proteins will hopefully allow researchers in the future to identify additional drug targets, and to better design therapies for colon cancer patients that kill cancer cells but spare the normal cells in the colon. "The discovery of the new role of APC may also help us understand why APC mutations are so prevalent in certain cancers but not others," says Lee. "Certain tissues may have a backup mechanism to put the brakes on the pathway when APC is mutated."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Memory Loss - Can it be Recovered?
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cancer and Homeopathy Colo-rectal cancer - Management Colorectal Cancer Cancer Facts Cancer Tattoos A Body Art Colon Crohns Disease Magical Millets for Your Health Diverticulosis and Diverticulitis 

Recommended Reading
Say 'No' to Red Meat to Prevent Colon Cancer
Consuming a diet free from red meat can reduce the risk of a type of colon cancer in women....
New Standard Set for Post-surgery Chemotherapy in Colon Cancer Patients
The standard six-month post-surgery course of chemotherapy may not be needed in some colon cancer .....
What Prevents Colon Cancer from Early Detection- Hidden Polyps
New insights into how these hidden polyps escape colonoscopy can help detect colon cancer early, ......
Novel Treatment Strategy Found for Colon Cancer Patients
Due to advances in screening techniques and improvements in treatments, the death rate from ......
Colo-rectal cancer - Management
Treatment for Colorectal Cancers may involve surgery,chemotherapy, radiation therapy or biological t...
Colorectal Cancer
Colorectal cancer is a cancer that starts in the colon or the rectum. Colorectal cancer is the third...
Crohns Disease
Crohn’s disease or regional enteritis is an inflammatory bowel disease that involves the small intes...
Diverticulosis and Diverticulitis
Diverticulosis is characterized by sac-like outpouching in the intestinal wall. Inflammation of div...
Magical Millets for Your Health
Millets are far more nutrient dense than wheat and rice. They are inexpensive and tasty too. Nutriti...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use