In chronic obstructive pulmonary disease (COPD) patients, depression is common and has been linked with disease severity and impaired quality of life.
Now, for the first time, researchers at the University of Pittsburgh have linked the systemic inflammation associated with COPD with depression in these patients.
Chronic Obstructive Pulmonary Disease
COPD includes respiratory tract disorders that cause obstruction to airflow. These are chronic bronchitis, emphysema and small airway disease.
Advertisement
"Systemic inflammation is thought to be an important mediator of comorbidities in COPD, but the relationship between inflammation and depression has not been explored," said researcher Hilary Strollo, M.S., a graduate of the University of Pittsburgh School of Health and Rehabilitation Sciences. "In our study, we found a strong association between depressive symptoms and levels of the inflammatory biomarker interleukin-6 (IL-6) which was independent of the severity of airflow obstruction."
The study results will be presented at the ATS 2013 International Conference in Philadelphia.
The study included 450 tobacco-exposed patients. Assessment included the Beck Depression Inventory (BDI), the Saint George Respiratory Questionnaire (SGRQ), and the UCSD Shortness of Breath Questionnaire (SOBQ). Spirometry and multi-detector computed tomography (MDCT) of the chest were also performed.
![Extended Use of Common Antibiotics may Cut Down on Hospitalization Rates Among COPD Patients]( "Extended Use of Common Antibiotics may Cut Down on Hospitalization Rates Among COPD Patients")
A comparison study reveals that extended used of antibiotics may prolong the time between hospitalizations for patients.
Of 235 male patients enrolled, 37 were depressed, and of 215 females, 49 were depressed. Clinical and biological variables that were found to be significantly associated with depression included the forced expiratory volume or FEV1, a measure of the maximum amount of air that can be exhaled in one second, gender, IL-6 levels, SGRQ Total Score, UCSD SOBQ Total Score, Visual Emphysema Score, and current smoking status.
The strongest associations were seen between depressive symptoms and FEV1, followed by female gender, current smoking status and increased IL-6.
"Depression has been linked with a number of symptoms and comorbidities in COPD patients," said Ms. Strollo. "Our findings add evidence of a strong relationship between depression and one of the hallmarks of COPD, systemic inflammation, independent of the severity of disease."
"The assessment and treatment of depression should be part of the routine care of COPD patients."
Source: Newswise
The study included 450 tobacco-exposed patients. Assessment included the Beck Depression Inventory (BDI), the Saint George Respiratory Questionnaire (SGRQ), and the UCSD Shortness of Breath Questionnaire (SOBQ). Spirometry and multi-detector computed tomography (MDCT) of the chest were also performed.
Extended Use of Common Antibiotics may Cut Down on Hospitalization Rates Among COPD Patients
A comparison study reveals that extended used of antibiotics may prolong the time between hospitalizations for patients.
Advertisement
Of 235 male patients enrolled, 37 were depressed, and of 215 females, 49 were depressed. Clinical and biological variables that were found to be significantly associated with depression included the forced expiratory volume or FEV1, a measure of the maximum amount of air that can be exhaled in one second, gender, IL-6 levels, SGRQ Total Score, UCSD SOBQ Total Score, Visual Emphysema Score, and current smoking status.
The strongest associations were seen between depressive symptoms and FEV1, followed by female gender, current smoking status and increased IL-6.
"Depression has been linked with a number of symptoms and comorbidities in COPD patients," said Ms. Strollo. "Our findings add evidence of a strong relationship between depression and one of the hallmarks of COPD, systemic inflammation, independent of the severity of disease."
"The assessment and treatment of depression should be part of the routine care of COPD patients."
Source: Newswise
COPD Is Associated With Significant and Persistent Pain: Study
Chronic obstructive pulmonary disease (COPD) is primarily associated with the respiratory symptoms that are its hallmark.
Advertisement
 Measuring Exercise Levels can Predict Hospitalization Risk Among COPD PatientsA new study suggests that measuring exercise levels of patients with COPD can predict whether or not they will end up needing hospitalization. | Advertisement
|
Advertisement
Recommended Readings
Latest Research News
South Korea's total fertility rate, averaging the number of children a woman aged 15-49 has in her lifetime, dropped to 0.81.
Scientists identified mechanisms governing immune cells, selectively removing troublemakers to reshape skin immunity. Benefits those with psoriasis, vitiligo.
By 2050, an anticipated increase from 494 million cases in 2020 to 1.06 billion people with musculoskeletal disabilities is expected.
Experts consulted by GlobalData anticipate a significant overhaul in the Gaucher disease scenario because of forthcoming gene therapies in development.
Within the seven major markets, 12% to 20% of diagnosed prevalent NASH cases present severe liver damage (stage 4 liver fibrosis), denoting cirrhosis.