About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

In Advanced Fibrosis Patients, Cardiovascular Issues Up Mortality Rates

by Bidita Debnath on April 11, 2013 at 5:04 PM
Font : A-A+

 In Advanced Fibrosis Patients, Cardiovascular Issues Up Mortality Rates

Advanced fibrosis is a significant predictor of mortality in patients with nonalcoholic fatty liver disease (NAFLD), largely brought about by cardiovascular causes, reveals new research.

NAFLD alone was not associated with increased mortality according to findings published in the April issue of Hepatology, a journal of the American Association for the Study of Liver Diseases.

Advertisement

With super-sized portions, sugary soft drinks and physical inactivity, obesity is on the rise and showing no sign of slowing. Studies report that the prevalence of obesity has doubled in the U.S. over the past 25 years. As obesity rates have soared, so has the incidence of NAFLD, making it the most prevalent liver disease in the U.S.

NAFLD is a chronic form of liver disease that includes such conditions as steatosis without fibrosis, nonalcoholic steatohepatitis (NASH) with fibrosis, and cirrhosis. Fibrosis is the progressive scarring of the liver with stages ranging from zero to four (cirrhosis). Medical evidence has found that patients with simple steatosis have a better prognosis than those with NASH, which could progress to end-stage liver disease.
Advertisement

Lead investigator Dr. W. Kim Ray from the Mayo Clinic in Rochester, Minn. explains, "The effect of NAFLD on public health is not well understood. Large, population-based studies, which can provide insight into disease activity, present some difficulty given that liver biopsy is required to confirm NAFLD."

To investigate the long-term impact of NAFLD on mortality, the team used data from the National Health and Nutrition Examination Survey (NHANES)—a survey by the National Center for Health Statistics in conjunction with the Centers for Disease Control and Prevention (CDC) that was conducted from 1988 to 1994 with mortality follow-up through 2006. NAFLD was diagnosed by ultrasound and severity of fibrosis was measured by non-invasive fibrosis markers such as the NAFLD fibrosis score (NFS).

Findings indicate that of the 11,154 participants, 34% had NAFLD, with 72% of these patients having a NFS that indicated lack of significant fibrosis (NFS less than -1.455) and 3% with advanced fibrosis (NFS greater than 0.676). NAFLD was not associated with higher mortality risk after a median of 15 years of follow-up.

Further analysis shows that mortality increases as fibrosis advances. In fact, patients likely to progress to advanced fibrosis had a 69% increase in mortality compared to those without fibrosis. Higher mortality in those with advanced fibrosis was largely due to cardiovascular causes, more than expected from conditions common in patients with NAFLD such as high blood pressure or high levels of cholesterol. "Our findings confirm that NAFLD patients without advanced fibrosis do not have higher mortality risk," concludes Dr. Kim. "Careful monitoring of disease progression in patients with NAFLD and fibrosis, along with interventions that reduce cardiovascular risk factors are warranted."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
First-Ever Successful Pig-To-Human Kidney Transplantation
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Fibroscan for Fatty Liver Cirrhosis and Fibrosis Retroperitoneal Fibrosis / Ormondīs Disease 

Recommended Reading
Cystic Fibrosis Drug by Pharmaxis Requires Another Trial to Get FDA Approval
FDA denies approval to market the drug, Bronchitol in USA....
Protein may Play a Key Role in Development of Fibrosis in Crohn's Disease
Researchers have found that a protein, known as IL-13, could play a pivotal role in the development ...
Study Tries to Explain Rise in New Type of Infection Among Cystic Fibrosis Patients
A joint study has shed more light on the rise of a new type of dangerous bacterial infection that .....
Cystic Fibrosis
Cystic fibrosis (CF) is an inherited or genetic disease involving the secretary glands, such as ......
Fibroscan for Fatty Liver Cirrhosis and Fibrosis
Recently, Fibroscan has incorporated the noninvasive Controlled Attenuation Parameter technique to e...
Retroperitoneal Fibrosis / Ormondīs Disease
Retroperitoneal fibrosis or Ormond's disease a rare disorder occurs when extra fibrous tissue forms ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use