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'Immunological Scarring' Occurs in Celiac Disease

by Mohamed Fathima S on February 18, 2019 at 2:34 PM
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'Immunological Scarring' Occurs in Celiac Disease

In celiac diseased individuals, the immune cells present in the intestines are permanently replaced by a new subset of cells that promote inflammation, reveals new research. Foundation for the progression of the disease is laid by this permanent 'immunological scarring,' which has long-term implications for gut health in diseased patients.

The results also suggest that the same process could be contributing to other chronic intestinal disorders, such as ulcerative colitis.

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Dr James McLaren, from Cardiff University's School of Medicine, said: "In celiac disease, T cells found in the bowel react to gluten and cause inflammation, which damages the lining of the bowel.

"Under normal circumstances, T cells have a protective role in the bowel and form a stable population. However, in celiac disease, they contribute to the inflammatory process, causing short-term symptoms and increasing the risk of developing certain types of bowel cancer.
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"Our new study suggests that even though short-term symptoms, such as diarrhea and abdominal pain, can be alleviated by removing gluten from the diet, long-term implications may remain, because 'tissue-healing' T cells in the bowel are permanently replaced by 'pro-inflammatory' T cells."

Celiac disease is common and affects one in 100 people. The international team hope the new findings will help inform the treatment of chronic intestinal disorders.



Source: Eurekalert
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