Being raised on a farm directly affects the regulation of the immune system and induces a decrease in the immunological responses to food proteins, finds a new study.
The research, led by the University of Bristol's School of Veterinary Sciences, found that spending early life in a complex farm environment increased the number of regulatory T-lymphocytes, the cells that damp down the immune system and limit immune responses.
"Many large-scale epidemiological studies have suggested that growing up on a farm is linked to a reduced likelihood of developing allergic disease. However, until now, it has not been possible to demonstrate direct cause and effect: does the farm environment actively protect against allergies, or are allergy-prone families unlikely to live on farms?" Marie Lewis, Research Associate in Infection and Immunity at the School of Veterinary Sciences, who led the research, said.
The work was carried out in piglets, as they are valuable translational models for humans since they share many aspects of physiology, metabolism, genetics and immunity.
They demonstrated that compared to their brothers and sisters in the isolator, the farm-reared piglets had reduced overall numbers of T-lymphocytes, the immune cells which drive immune responses, in their intestinal tissues. Importantly, these dirty piglets also had significantly increased numbers of a subset of these cells, the regulatory T-lymphocytes, which pacify immune responses and limit inflammation.
This shift in the ratio of stimulatory and regulatory cells appeared to have functional effects since the farm-reared piglets also exhibited decreased antibody responses to novel food proteins when they were weaned.
Regulatory T-cells have been identified in many mammalian species, including humans, and appear to be universal regulators of immune systems and a reduction in their numbers is often associated with the development of allergies, autoimmune and inflammatory diseases.
"At this point it is not clear exactly what caused the increased capacity for immune regulation in our farm-reared piglets. Our previous work suggests that intestinal bacteria play a pivotal role in the development of a competent immune system and these bacteria are obtained from the environment during early life," Lewis added.