Lung cancer occurs due to the abnormal proliferation of cancer cells in the lung. FDG PET/CT scan (Fluoro-D-glucose-positron emission tomography/Computed Tomography) is a valuable imaging tool for assessing treatment in lung cancer patients.The effectiveness of these imaging tool is still compared with conventional imaging like chest CT. Authors of the study titled "The Value of FDG PET/CT in Treatment Response Assessment, Follow-Up, and Surveillance of Lung Cancer" published their findings in the February 2017 issue of the American Journal of Roentgenology. The study is available on the ARRS website accessible here.
‘FDG PET/CT (Fluoro-D-glucose-positron emission tomography/Computed Tomography) scan is a valuable imaging tool to assess treatment for lung cancer patients.’
In this review, the authors summarized the existing evidence in the literature concerning use of PET/CT for both assessing the efficacy of treatment response and performing posttreatment follow-up of lung cancer."FDG PET/CT is most useful when there is clinical suspicion or other evidence for disease recurrence or metastases," said study coauthor Rathan M. Subramaniam, of the department of radiology, University of Texas Southwestern Medical Center, Dallas. "Using FDG PET/CT for routine surveillance without any clinical suspicion should be discouraged until its value for patient survival outcomes is fully established."
The National Comprehensive Cancer Network (NCCN) recommends the use of FDG PET/CT for appropriately staging lung cancer and avoiding futile thoracotomies. It also recommends the imaging for accurate radiation therapy (RT) planning for both non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). However, NCCN does not recommend routine use of FDG PET/CT for treatment response evaluation and follow-up in lung cancer.
According to the study authors, FDG PET/CT is usually recommended to be performed 12 weeks after completion of concurrent chemoradiation therapy to minimize radiation-related inflammatory uptake leading to false-positive studies. In some cases, radiation-related therapy changes, especially with stereotactic body radiotherapy, can last for many months. In these circumstances, a follow-up FDG PET/CT in 3 months is suggested to ensure resolution of therapy-related FDG uptake. FDG PET/CT can be performed 4 weeks after completion of chemotherapy or surgery (without concurrent radiation), because the therapy-related inflammatory uptake is less and subsides within a shorter time.
The sequencing, cost analysis, and comparative effectiveness of FDG PET/CT and conventional imaging modalities in the follow-up setting need to be investigated.
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Lung cancer has historically been divided into two main types: NSCLC (85% of cases) and SCLC (10-15% of cases). A multidisciplinary approach including the use of advanced imaging techniques for early accurate staging of disease and delivery of treatment is needed to avoid futile treatments and improve overall survival, which, in turn, influence the patient's quality of life.
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Source-Eurekalert