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ICMR Starts Vaccine Trial to Prevent TB Among Close Contacts of Patient

by Iswarya on July 16, 2019 at 9:44 AM
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ICMR Starts Vaccine Trial to Prevent TB Among Close Contacts of Patient

Indian Council of Medical Research (ICMR) begins a vaccine trial to prevent the occurrence of TB (tuberculosis) among people present close to patients suffering from it.

This is the first-ever government conducted vaccine trial after the BCG vaccine trial that was undertaken decades ago.

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This vaccine trial is an important step in prevention and decreasing the burden of this disease, said a release from ICMR.

"After a detailed landscape analysis of the available lead vaccine candidates, two potential vaccine candidates - VPM 1002 produced by Serum Institute of India in Pune and Mycobacterium Indicus Pranii (MIP) were shortlisted for taking forward through the phase III vaccine trial in healthy household contacts of sputum smear-positive TB patient," the ICMR said in a statement.
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The study will test the safety and efficacy of these two vaccines by administering them in close TB contacts as opposed to a control group of close TB contacts who will not receive the vaccine. The study will enroll 12,000 healthy household contacts of sputum smear-positive TB cases that are at high risk of contracting the disease, from seven sites in six states - Delhi, Karnataka, Maharashtra, Orissa, Tamil Nadu, and Telangana.

Balram Bhargava, Secretary, Department of Health Research and Director General, ICMR said the clinical trials are needed in India to show that the vaccine is safe and effective and that it can provide protection to Indian populations where the disease is endemic.

Rohit Sarin, Director, National Institute of Tuberculosis and Respiratory Diseases (NITRD) said that this is the much-awaited trial and assured full support in timely completion of the trial.

The study has been started first at NITRD, New Delhi on Monday and would be subsequently initiated at other sites. ICMR aims at completing the enrolment in all sites within the next seven to eight months.

Source: IANS
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