Nonsteroidal anti-inflammatory medication like ibuprofen is found to be safe for patients with fractures. It doesn't delay bone healing, as found in animal models, as well as in some spinal fusion cases.
The study examined 95 skeletally immature children with fractures. Forty-six patients in the control group received acetaminophen for pain, while 49 patients in the NSAID group received ibuprofen.
Six weeks after surgery, 82% of the control group and 92% of the ibuprofen group had healed fractures. At 10-to-12 week follow-ups, 98% of the control group and 100% of the ibuprofen group had healed.
"I think this study will be especially important when the patient first presents to the emergency department. The physician there should feel comfortable prescribing ibuprofen in addition to acetaminophen as a safe and effective pain reliever that won't hinder a child's bone healing."
Patients in the control and ibuprofen groups reported similar pain management scores during the first three days after injury and at each follow-up interval. For the control group, acetaminophen was used for 3.9 days on average while the ibuprofen group average was 4.3 days.
"We often find that pain management is not adequate with just acetaminophen," Gupta said. "Patients respond better to having two medications at the same time. So if that second medication can be ibuprofen instead of a narcotic, that's a much safer alternative."
Gupta believes the results from this study warrant further investigation to examine the effectiveness of other NSAID drugs besides ibuprofen, how NSAIDs work on specific types and locations of fractures and the effectiveness of this treatment on specific patient profiles, including adults.