Previous research has shown that transient receptor potential channel A1 is one of the important transducers of noxious stimuli in the primary afferents. The latter may contribute to generation of neurogenic inflammation and hyperalgesia. However, there is no direct evidence that activation of transient receptor potential channel A1 contributes to neuropeptide release from primary afferent neurons. A recent study by Yi Dai and team from Hyogo College of Medicine in Japan demonstrated for the first time that allyl isothiocyanate (AITC; also known as mustard oil) activates transient receptor potential channel A1, resulting in calcitonin gene-related peptide release from the cultured rat dorsal root ganglion neurons. Knockdown of transient receptor potential channel A1 with an antisense oligodeoxynucleotide prevented calcitonin gene-related peptide release by allyl isothiocyanate application in cultured dorsal root ganglion neurons. Thus, the researchers concluded that transient receptor potential channel A1 activation caused calcitonin gene-related peptide release in sensory neurons. These findings were published in the Neural Regeneration Research (Vol. 8, No. 32, 2013). Source: Eurekalert << British Surgeon Suspended for Branding His Initials on a Pa... Neuroprotective Effects of Hypoxic Preconditioning Linked W... >> Recommended Reading Abdominal Pain Abdominal pain occurs due to multiple causes. Pain due to obstruction in the small intestine appears around or above the umbilicus or belly button. Type of abdominal pain may vary from mild to severe. READ MORE Back Pain at Workplace: Prevention and Exercises Understanding the basics about our back and our posture is very important in preventing back pain and improving workplace productivity. READ MORE Back Pain Back pain or Backache is common due to poor posture, postural deformities and life style. Back pain can be classified anatomically as upper, lower and middle back pain. READ MORE Cancer Pain Every 1 out of 3 people undergoing cancer treatment experiences pain. READ MORE Most Popular on Medindia Sanatogen Daily Calorie Requirements Vent Forte (Theophylline)
Previous research has shown that transient receptor potential channel A1 is one of the important transducers of noxious stimuli in the primary afferents. The latter may contribute to generation of neurogenic inflammation and hyperalgesia. However, there is no direct evidence that activation of transient receptor potential channel A1 contributes to neuropeptide release from primary afferent neurons. A recent study by Yi Dai and team from Hyogo College of Medicine in Japan demonstrated for the first time that allyl isothiocyanate (AITC; also known as mustard oil) activates transient receptor potential channel A1, resulting in calcitonin gene-related peptide release from the cultured rat dorsal root ganglion neurons. Knockdown of transient receptor potential channel A1 with an antisense oligodeoxynucleotide prevented calcitonin gene-related peptide release by allyl isothiocyanate application in cultured dorsal root ganglion neurons. Thus, the researchers concluded that transient receptor potential channel A1 activation caused calcitonin gene-related peptide release in sensory neurons. These findings were published in the Neural Regeneration Research (Vol. 8, No. 32, 2013). Source: Eurekalert << British Surgeon Suspended for Branding His Initials on a Pa... Neuroprotective Effects of Hypoxic Preconditioning Linked W... >> Recommended Reading Abdominal Pain Abdominal pain occurs due to multiple causes. Pain due to obstruction in the small intestine appears around or above the umbilicus or belly button. Type of abdominal pain may vary from mild to severe. READ MORE Back Pain at Workplace: Prevention and Exercises Understanding the basics about our back and our posture is very important in preventing back pain and improving workplace productivity. READ MORE Back Pain Back pain or Backache is common due to poor posture, postural deformities and life style. Back pain can be classified anatomically as upper, lower and middle back pain. READ MORE Cancer Pain Every 1 out of 3 people undergoing cancer treatment experiences pain. READ MORE Most Popular on Medindia Sanatogen Daily Calorie Requirements Vent Forte (Theophylline)