About Careers MedBlog Contact us

Hydrogen Sulfide Gas Helps Lower Heart Rate, Blood Pressure, Blood Vessel Stiffness

by Dr. Trupti Shirole on February 1, 2015 at 12:16 PM
Font : A-A+

 Hydrogen Sulfide Gas Helps Lower Heart Rate, Blood Pressure, Blood Vessel Stiffness

A new compound, called AP39, which generates minute quantities of hydrogen sulfide gas inside cells, could be beneficial in cases of high blood pressure and diseases of the blood vessels that occur with ageing and diabetes, according to scientists at University of Exeter Medical School.

Animal studies of AP39 have revealed that administration of the compound to animals with high blood pressure significantly lowered heart rate, blood pressure and blood vessel stiffness.


Researcher Matt Whiteman, who led the study, said, "This research significantly adds to our growing body of evidence that hydrogen sulfide could hold the key to new and effective therapies in humans. We are still at an early stage, but so far the key to success appears to be getting hydrogen sulfide delivered to the right place inside cells and mimicking the way the body naturally produces this gas. The mechanism may be through blocking a calcium channel on the heart that regulates heartbeat, slowing it down. Clinically used drugs which also block this channel have similar effects, but more than 10 fold higher doses are required."

The research team is currently investigating the effects of AP39 in other models of heart and blood vessel disease, such as cardiac arrest and heart attacks.

The study has been published in the Nitric Oxide Journal.

Source: Medindia


Recommended Reading

Latest Heart Disease News

Monday: The Day for Deadly Heart Attacks?
The start of the week is when most fatal heart attacks occur, according to a study.
Delay in Seeking Care Results in 55% of Cardiac Deaths in India
The first community-based study, published in the journal Lancet, says that delays in seeking care account for nearly 55% of the reported cardiac and stroke deaths in India.
The Surprising Impact of Quit Smoking: 36% Lower Cardiovascular Risk
The study emphasizes the existing proof on the heart disease risks of tobacco smoking and the urgent need to stop smoking among cancer survivors.
 Discovering Genetic Risks for Type of Heart Attack Largely Affecting Younger Women
New study findings provide novel pathophysiological insights involving blood vessel integrity and tissue-mediated coagulation in a type of heart attack in young women.
Unlocking the Crystal Ball: Heart Failure Subtypes Helps Forecast Future Risks!
Recent study identifies five heart failure subtypes with the potential for individual patient risk prediction.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Hydrogen Sulfide Gas Helps Lower Heart Rate, Blood Pressure, Blood Vessel Stiffness Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests