Population studies and other human-focused research suggests that
one's risk of developing Alzheimer's disease and other dementias can be
reduced with changes to diet and other modifiable lifestyle factors.
Nutrition researcher Neal D. Barnard and other speakers at the
American Association for the Advancement of Science's Annual Meeting
call for a new approach to research on Alzheimer's disease and related
dementias. Since decades of animal experiments have failed to produce
meaningful treatments or cures, the focus must shift to human-relevant
‘Since decades of animal experiments have failed to produce meaningful treatments or cures for Alzheimer's disease and dementia, the focus must shift to human-relevant research.’
Ann Lam, senior medical research specialist at the
Physicians Committee for Responsible Medicine and co-director of the
Green Neuroscience Laboratory, Neurolinx Research Institute, said, "Research
with human patients and populations holds the greatest promise."
In her talk, "Roads to Dementia Prevention: Leveraging the Past and
Enabling the Future," Dr. Au will present on the historical significance
of the Framingham Heart Study as well as her recent findings which show
the untapped potential to better understand preclinical Alzheimer's
using real-time data and other aspects captured with current technology.
In addition, she will discuss the limitations of current diagnostic
methods and how IoT can advance studies of modifiable risk factors for
dementia and spawn solutions for precision health of dementia.
Dr. Barnard's talk "Alzheimer's Disease: Prevention Through Dietary
Interventions," will provide an overview of the failures in translation
from animal models in Alzheimer's research and the rapidly refining
human-based approaches and clinical studies on prevention of dementia.
He will present examples of global communities that are highly engaged
in prevention research and are models of harmonizing traditional
knowledge and perspectives on lifestyle factors. He will also describe
how to better integrate nutrition and lifestyle factors into research
In her talk "The Need for National Engagement in Alzheimer's Disease
Prevention Strategies," Dr. Langbaum will present an overview of the
evolution and strategies of the state-wide Arizona Alzheimer's Registry
to the nationwide Alzheimer's Prevention Registry and discuss the
enormous potential of engaging citizens in science at the national
level. She will also show how new infrastructure for prevention research
can unlock potential for individuals to change perceptions on their
role in research and educate participants in their impact in scientific
discoveries and health policy.