Medindia
Advertisement

Human Organoids Hasten Drug Development & Personalized Treatments

by Ramya Rachamanti on December 31, 2018 at 11:29 AM

Human Organoids Hasten Drug Development & Personalized Treatments
Human organoids are considered a significant development in biomedicine, as per a report issued by the American Society for Cell Biology (ASCB) which will be released at a session 2018 ASCB|EMBO Meeting in San Diego, CA.

According to the report, human organoids "have the potential to overcome a number of previous limitations in biomedical research" and will allow researchers to gain "insights into human development, generating accurate models of human disease, and developing authentic and patient-specific tissue sources for regenerative medicine."
Advertisement


An Organoid Task Force, assembled by ASCB and led by Ruth Lehmann, Director of the Skirball Institute of Biomolecular Medicine at New York University School of Medicine, recognized the wealth of opportunities human organoid research will provide to life science investigators. The task force also uncovered a series of challenges that both science and society will have to address in light of this new scientific tool.

The potential applications for organoid research include:

Improvements in the study of human developmental biology,
The unique ability to identify the mechanisms of human disease,
Tremendous potential for applications in tissue engineering and regenerative medicine,
Development of patient-specific clinical models for personalized drug development,
Significant reduction in cost and time for development of prescription drug development.
Advertisement

"Along with the enormous potential human organoids offer, there are also a number of challenges for both science and society that will have to be addressed," Lehmann said.

These challenges include addressing issues of reproducibility from experiment to experiment and between laboratories seeking to replicate research findings. Solving the issue of reproducibility may well determine the ultimate utility of organoids to the scientific community.

Training is also a significant hurdle to the advancement of the field. As the report states, "the development of well-structured organoids requires long periods of time (many months to years) and is not easily translated from one type of organoid to the next." The report goes on to say that "hands-on training in these protocols is difficult and protocols can be challenging to reproduce at different geographical locations."

Patient consent will also be a significant challenge to the future of organoid research, which will depend heavily on an adequate supply of properly consented human tissue. The ASCB paper includes detailed recommendations for developing methods of consent for future research.

Task Force members Lehmann, Connie Lee (University of Chicago), and Jürgen Knoblich (Institute of Molecular Biotechnology/Vienna, Austria) will participate in a virtual press conference online. To access the meeting click on https://zoom.us/j/156843017.

The report will be presented at the 2018 ASCB|EMBO Meeting at the San Diego Convention Center in room 33B. To access an embargoed version of the report, go to https://preview.tinyurl.com/ASCB-organoid-rpt.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Stroop Effect
Plant-Based Diet may Reduce the Risk of COVID-19
Lower Respiratory Tract Infections Linked to Obstructive Sleep Apnea in Children
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Signature Drug Toxicity Drugs Banned in India 

Recommended Reading
Providing Brain Organoids With the Supportive Physiological Environment
Developing more sophisticated organoid models by ensuring they receive sufficient oxygen and other ....
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Drugs Banned in India
Several drugs are either banned or withdrawn after introduction in the market....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use