HPV Vaccine Can Help Treat Patients With Skin Cancer

Human papilloma virus (HPV) vaccine can be used to treat patients with skin cancer, reports a new study. The findings of the study are published in JAMA Dermatology.

Squamous cell carcinoma is the second-most-common form of skin cancer. Evidence suggests the human papilloma virus plays a role in the development of some types of this skin cancer.

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‘HPV vaccine can treat patients with skin cancer. HPV vaccine Gardasil is only approved for the prevention of cervical, anal, vulvar and vaginal cancers caused by the human papilloma virus. Using Gardasil, as an off-label treatment reduced the number of new basal and squamous cell skin cancers in two patients.’

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Two years ago, a 97-year-old woman whose right leg was covered with squamous cell tumors went to see dermatologist Anna Nichols, M.D., Ph.D., at Sylvester Comprehensive Cancer Center. Surgery is the standard of care for most patients with skin cancer.

"She was not a candidate for surgery because of the sheer number and size of her tumors. She wasn't a candidate for radiotherapy, again for the same reasons," said Dr. Nichols, an assistant professor at the University of Miami Miller School of Medicine.

In 2017, a case report by Dr. Nichols showed the HPV vaccine Gardasil reduced the number of new basal and squamous cell skin cancers in two patients. Tim Ioannides, M.D., a voluntary faculty member at UM, suggested using the vaccine as an off-label treatment by directly injecting it into the tumors.

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Since her patient had no other options, Dr. Nichols offered her the treatment. It is considered an "off-label" use because Gardasil is only approved for the prevention of cervical, anal, vulvar and vaginal cancers caused by the human papilloma virus.

"I think we had a really reasonable expectation and good data that this was actually going to, at the very least, do no harm to this patient, and possibly provide some benefit," said Dr. Ioannides. "To have this type of result in such an advanced patient I think was beyond all our expectations."

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The patient was first given two doses of the 9-valent HPV vaccine in her arm, six weeks apart. A few weeks later Dr. Nichols directly injected several but not all of the patient's tumors. The direct intratumoral injections were given four times over 11 months.

"All of her tumors completely resolved 11 months after the first direct tumor injection, and she has had no recurrence," Dr. Nichols said. "It has been about 24 months now since we started with the treatment."

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"They decided to try it, and it worked. It killed them all off," said the patient, who is now looking forward to celebrating her 100th birthday this fall.

Source-Eurekalert