About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

How Type 2 Diabetes Develops Demystified in New Mouse Model

by Kathy Jones on May 5, 2013 at 7:45 PM
Font : A-A+

 How Type 2 Diabetes Develops Demystified in New Mouse Model

A new mouse model that answers the question of what actually happens in the body when type 2 diabetes develops has been developed by researchers at Lund University in Sweden.

Long-term studies of the middle-aged mouse model will be better than previous studies at confirming how drugs for type 2 diabetes function in humans."The animal models for type 2 diabetes studies that have previously existed have not been optimal because they use young mice. Our idea was to create a model that resembles the situation in the development of type 2 diabetes in humans. We generally get the disease in middle age when we start to put on weight and live a more sedentary, and more stressful, life. Our new middle-aged mouse model has enabled us to study long-term physiological effects of the development and treatment of type 2 diabetes in a completely new way", said Bilal Omar, one of the researchers behind the study.

Advertisement

What the Lund researchers have done is to feed normal mice fatty food over a long period from the age of eight months, i.e. middle age, until the end of their natural lives at the age of two. The mice become overweight, and develop high blood sugar levels and reduced insulin release, as expected before the onset of type 2 diabetes."Throughout the period we were able to study the process that leads to the development of type 2 diabetes with a lifestyle like that of people predisposed to the condition", said Bilal Omar.In the study, the researchers could confirm that fatty foods lead to inflammation in the islets of Langerhans in the pancreas, which produce insulin. Researchers have seen inflammation in the islets in people with type 2 diabetes, but in Bilal Omar's view, it is only with the new mouse model that it can really be confirmed. Inflammation in these islets is an important risk factor for type 2 diabetes."What was so interesting and exciting was that the mice that were treated with DPP-4 inhibitors, a class of drugs used for type 2 diabetes, did not develop inflammation and they maintained good insulin production. They were still obese, but had normal blood sugar, were otherwise healthy and lived longer", said Bilal Omar.Researchers have worked for decades and on many fronts to understand the causes and course of diabetes. Models of different diseases are therefore an important tool for the development of new and better drugs, and a requirement to develop the best possible drugs is to understand what is happening on a physiological level. "The goal is to design drugs and treatments which, if they can't cure the disease, can at least give the patient a better quality of life for several years", said Bilal Omar."Another aspect of our findings is that the inflammation in the islets was caused by a high-fat diet. Even if it is too early to draw parallels with the diet of humans, it makes it doubtful whether a high-fat diet over a long period should be recommended, as in the LCHF diet", said Professor Bo Ahrén, another of the researchers behind the study.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Diabetic Retinopathy Diabetes Diabetic Diet Otitis Media Diabetes - Essentials Diabetes - Self-Monitoring of Blood Glucose (SMBG) Insulin Delivery Devices Diabetes and Exercise Stress Relief Through Alternative Medicine Stress and the Gender Divide 

Recommended Reading
Type 2 Diabetes
Globalization and changing lifestyles has made diabetes very common in developing countries so much ...
Diabetes - Foot Care
Valuable information on diabetic foot care, treatment and prevention....
Diabetes
A comprehensive article on diabetes - both Type 1 and Type 2 diabetes, including : causes, signs, .....
Diabetes - Essentials
Diabetes is a metabolic disease caused by insulin deficiency that leads to high blood sugar levels a...
Diabetes - Self-Monitoring of Blood Glucose (SMBG)
Self-Monitoring Of Blood Glucose (SMBG) is one of the greatest advancements in the management of Di...
Diabetes and Exercise
Regular exercise especially in type II diabetes not only helps reduce the sugar but also reduces the...
Diabetic Diet
The diabetic diet most often recommended is high in dietary fiber (especially soluble fiber) and nut...
Diabetic Retinopathy
The term ‘diabetic retinopathy’ refers to changes in the retina which often occur in people with ......
Insulin Delivery Devices
Insulin delivery devices have evolved drastically since their invention in 1922. They are all aimed ...
Otitis Media
Middle ear infection, or otitis media, is a common type of infection that may or may not accompany t...
Stress and the Gender Divide
Stress has become entwined in the current lifestyle of a young working couple and has resulted in th...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use