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The way in which the brain sometimes may fail to tell the body that 'it is full' after a hearty meal has been discovered by scientists.
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Leptin is a hormone released by fat cells that is known to indicate fullness in the brain. But too much of it and the body becomes immune to the hormone.
When that happens, the body "can't hear" the hormonal messages telling it to stop eating and burn fat.
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For the study, the researchers induced leptin resistance in organotypic brain slices from mice.
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They also found that when the pathway was blocked, the cells were no longer resistant to leptin.
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"These results are potentially interesting and provocative, but the physiological importance remains to be seen. If, however, this pathway is indeed important, it will offer new insights into the mechanisms that high levels of leptin cause in leptin resistance," said Elmquist.
The study will appear in the March issue of Cell Metabolism.
Source-ANI
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