The researchers observed a group of 29 medical residents who were working in intensive care unit, a work environment which triggers chronic stress among the staff. The participants were given stress perception questionnaires and their blood samples, taken both during and after their shifts, were analyzed.
The researchers found that stress led to overproduction of white blood cells by the bone marrow stem cells. On shifting the study to a group of mice that had a higher risk of atherosclerosis, the researchers found that the surplus white blood cells tended to stick to the inner walls of arteries, leading to restricted blood flow and formation of clots which increases the risk of stroke or heart attack.
"When atherosclerosis-prone mice were subjected to chronic stress, accelerated (blood cell production) promoted plaque features associated with vulnerable lesions that cause (heart attack) and stroke in humans. Taken together, these data provide further evidence of the hematopoietic system's role in cardiovascular disease, and elucidate a direct biological link between chronic variable stress and chronic inflammation, a general concept with implications beyond atherosclerosis", lead researcher Professor Matthias Nahrendorf said.