University of Kent researchers have identified human stress hormone cortisol as the key factor when the immune system fails to prevent leukemia taking hold.
They do this by using cortisol to force the release of a protein, latrophilin 1. This in turn causes the secretion of another protein, galectin-9, which suppresses the body's natural anti-cancer immune mechanism.
‘AML cells employ a unique pathway to progress the disease, using functional systems of the human body to both support their survival and also reduce the anticancer activities of immune cells.’
Dr Sumbayev's team, working with researchers from two German universities and the UK's Diamond Light Source facility, found that although healthy human white blood cells are not affected by cortisol they become capable of releasing latrophilin 1 when malignant transformation takes place.
Malignant AML cells then use cortisol to increase the release of latrophilin 1 so that they can use it to avoid the immune system.
The study concluded that galectin-9, as well as a natural binding partner of latrophilin 1 - known as FLRT3 - which are both present in human blood plasma, are the most promising targets for future anti-AML immune therapy.
Dr Sumbayev said: 'For the first time, we can identify a possible future pathway to develop an effective new therapy using the body's natural immune mechanisms. We have discovered a new fundamental biochemical mechanism within the human body that allows AML cells to employ physiological systems to survive and escape immune attack.'