How Stress Hormone Cortisol Prevents Leukemia?

by Colleen Fleiss on  August 16, 2018 at 9:45 AM Cancer News
RSS Email Print This Page Comment bookmark
Font : A-A+

University of Kent researchers have identified human stress hormone cortisol as the key factor when the immune system fails to prevent leukemia taking hold.
How Stress Hormone Cortisol Prevents Leukemia?
How Stress Hormone Cortisol Prevents Leukemia?

They do this by using cortisol to force the release of a protein, latrophilin 1. This in turn causes the secretion of another protein, galectin-9, which suppresses the body's natural anti-cancer immune mechanism.

Dr Sumbayev's team, working with researchers from two German universities and the UK's Diamond Light Source facility, found that although healthy human white blood cells are not affected by cortisol they become capable of releasing latrophilin 1 when malignant transformation takes place.

Malignant AML cells then use cortisol to increase the release of latrophilin 1 so that they can use it to avoid the immune system.

The study concluded that galectin-9, as well as a natural binding partner of latrophilin 1 - known as FLRT3 - which are both present in human blood plasma, are the most promising targets for future anti-AML immune therapy.

Dr Sumbayev said: 'For the first time, we can identify a possible future pathway to develop an effective new therapy using the body's natural immune mechanisms. We have discovered a new fundamental biochemical mechanism within the human body that allows AML cells to employ physiological systems to survive and escape immune attack.'

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions
Advertisement

Recommended Reading

More News on:

Palpitations And Arrhythmias Stress Relief Through Alternative Medicine Stress and the Gender Divide Andropause / Male Menopause Heart Attack- Lifestyle Risks Addison’s Disease Adreno Cortical Carcinoma Is Your Man Moody? Diabesity Tired All The Time 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive