How Stem Cells Make Skin

by Rajashri on September 15, 2009 at 8:20 PM
 How Stem Cells Make Skin

Two proteins that prompt stem cells to develop into skin cells have been identified by scientists at the European Molecular Biology Laboratory (EMBL).

They hope that the new findings could help understand basic mechanisms involved not only in formation of skin, but also on skin cancer and other epithelial cancers.


According to lead researcher Claus Nerlov, at some point, the stem cells at the base of the skin stop proliferating and start differentiating into the cells that form the skin itself.

To do so, they must turn off the 'stem cell programme' in their genes and turn on the 'skin cell programme'.

It is believed that a family of proteins called C/EBPs might be involved in this process.

They are known to regulate it in other types of stem cell, however which C/EBP protein controlled the switch in skin was not known.

Nerlov and his group at EMBL Monterotondo have discovered two proteins called C/EBPa and C/EBP.

After removing the genes that encode C/EBPa and specifically in the skin of mouse embryos, the study showed that without these proteins the skin of the mice did not form properly.

"Mice with neither C/EBPa nor had taut and shiny skin that couldn't keep the water inside their bodies," Nature magazine quoted Nerlov as saying.

"They lacked many of the proteins that make skin mechanically strong and water tight, and they died of de-hydration shortly after birth," Nerlov added.

However, a single working copy of either the gene for C/EBPa or the gene for C/EBP was enough to ensure that skin developed properly.

The study appears in Nature Cell Biology.

Source: ANI
Font : A-A+



Recommended Readings

Latest Genetics & Stem Cells News

New Gene Therapy to Treat Genetic Brain Disorder
NGN-401 is a first ever new gene therapy discovered to cure a rare genetic brain disorder called Rett Syndrome.
Early-Stage Stem Cell Trial for Progressive Multiple Sclerosis
Among MS patients, the stem cells showed a neuroprotective role, guarding nerve cells from further decline.
Human Genetics Unravels Mysteries of Digestive Disorders
New possibilities for research on digestive diseases have been set by complete decoding of the Y chromosome.
World's First CRISPR-Based Gene Therapy for Blood Disorders
UK has given the green light to the world's inaugural gene therapy for sickle-cell disease and thalassemia.
Genotype Linked to Short-Lifespan Affects 1 in 25 People
1 in 25 people had a genotype linked to short lifetime, which includes BRCA2 and LDLR genes, that reduced lifespan by seven years, and six years respectively.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

How Stem Cells Make Skin Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests