About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

How Our Circadian Clocks Regulate Energy Metabolism

by Megha Ramaviswanathan on March 9, 2018 at 4:16 PM
Font : A-A+

How Our Circadian Clocks Regulate Energy Metabolism

A new research has found that how exactly the 24 hour circadian rhythm regulates energy metabolism in the body. According to the study, circadian clocks present inside different parts of the body such as the liver, kidneys and heart help to initiate many metabolic processes of the body at the optimal time.

The study is published in the journal Cell Metabolism and involved scientists from the University of Basel, University of Zurich and University Psychiatric Clinics Basel (UPK Basel).

Advertisement


Fission protein sets the rhythm
In most cells, mitochondria connect in a constantly changing network that can adapt to various conditions. Mitochondria can thus fuse together and then divide again. Disruption of this fission-fusion dynamic can lead to health problems.

Scientists have now investigated exactly how the mitochondrial network interacts with our internal biological clock by using a combination of in vitro models and clock-deficient mice or mice with impaired mitochondrial fission.
Advertisement

Their results show that the mitochondrial fission-fusion cycle is controlled by the fission protein Drp1, which is in turn synchronized by an internal biological clock. This rhythm is integral to determining when and how much energy the mitochondria can supply.

"The time of day determines the design of the mitochondrial network, and this, in turn, influences the cells' energy capacity," explains study leader Professor Anne Eckert from the University of Basel's Transfaculty Research Platform Molecular and Cognitive Neurosciences MCN.

Relationship between circadian clock and energy production
The scientists also showed that the mitochondrial network loses its rhythm if the circadian clock is impaired, which causes a decline in energy production in the cells.

Similarly, pharmacologically or genetically impairing the Drp1 fission protein upsets the energy production rhythm, which in turn affects the rhythm of the circadian clock.

These findings could play a role in the development of new therapeutic approaches; for example, for diseases that are characterized by an impaired circadian clock and compromised mitochondrial function, such as Alzheimer's disease.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
January is the Thyroid Awareness Month in 2022
Menstrual Disorders
Coffee May Help You Fight Endometrial Cancer
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Resting Metabolic Rate Galactosemia Top 10 Ways to Speed up Your Metabolism For Weight Loss 

Recommended Reading
Circadian Rhythm Boosts Body's Response to Intestinal Infections
Circadian rhythms boost the body's ability to fight intestinal bacterial infections. Targeted ......
Study Identifies How Internal Circadian Clocks Encode External Daily Rhythms of Excitability
A mechanism through which circadian clocks in neurons encode external daily rhythms of excitability ...
Circadian Rhythm may Help Regulate Inflammatory Diseases
Controlling of the circadian rhythm or biological clock may help reduce the severity of ......
Protein That Controls Body’s Circadian Rhythms Identified
Disruptions to circadian rhythm can alter the appetite and sleep patterns for days-and even ......
Galactosemia
Galactosemia is one of many genetically inherited diseases and it affects one’s ability to process g...
Resting Metabolic Rate
Understanding how metabolic process is regulated and what factors affect the same is crucial before ...
Top 10 Ways to Speed up Your Metabolism For Weight Loss
Boosting metabolism is what we need to pump our weight loss regime. Slow body metabolism can be the ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)