Vaccine Response Influenced by Circadian Rhythm
Research author Professor Annie Curtis, School of Pharmacy and Biomolecular Sciences at RCSI said: “Our discovery has shed light on a crucial aspect of our body’s response to vaccination and highlights the importance of circadian rhythms in immunity. We can apply this understanding in vaccine development to ensure we receive the maximum benefits from vaccination.”
Circadian Rhythm Sleep Disorders - Types, Causes, Health risks, Diagnosis, Treatment, Prognosis
Circadian rhythm (also known as sleep/wake cycle or the body clock) is a biological process that follows an internal cycle of roughly 24 hours.
Circadian rhythm (also known as sleep/wake cycle or the body clock) is a biological process that follows an internal cycle of roughly 24 hours.
‘The new study examined the changes taking place in the mitochondria of a key immune cell involved in the vaccine response and could help improve the design and timing of administration of future vaccines to maximize effectiveness.’
Tweet it Now
The circadian clock within dendritic cells is controlling whether mitochondria form one of two shapes either long strings, ‘networked’, or broken into small punctate pieces. It is within the networked formation that vaccination is most effective as dendritic cells have a better ability break up the vaccine into small pieces for interaction with our immune cells (T cells). Within the study, researchers used an approach to induce the networked phase which could have implications in vaccine design allowing us to optimise our immune response, irrespective of time of day. The majority of this study was supported through funding provided by the Science Foundation Ireland Career Development Award (CDA) programme by the Irish Research Council through a Laureate Award and an RCSI Strategic Academic Recruitment Program (StAR) award. Further support was provided by a Conacyt grant, a SFI Investigator Award and a European Research Council Consolidator Award.
Source-Eurekalert
Travel Vaccination Calculator
Find out about travel shots or vaccination before you travel to your destination country. Travel vaccination calculator guides travelers on information about travel to 247 countries. Safe travel is the first step to enjoy your holiday or business travel.
Find out about travel shots or vaccination before you travel to your destination country. Travel vaccination calculator guides travelers on information about travel to 247 countries. Safe travel is the first step to enjoy your holiday or business travel.
Irregular Body Clock Plays a Role in the Most Prevalent Diseases
A new link between a disrupted body clock and inflammatory diseases discovered. Insufficient sleep and not enough daylight - factors that impact body clocks can also impact the ability of the immune system.
A new link between a disrupted body clock and inflammatory diseases discovered. Insufficient sleep and not enough daylight - factors that impact body clocks can also impact the ability of the immune system.
Excess Fat Disturbs the Body Clock
New research can be a cornerstone for future clinical studies that could restore the proper functioning of the body clock in the brain, to avoid overeating and obesity.
New research can be a cornerstone for future clinical studies that could restore the proper functioning of the body clock in the brain, to avoid overeating and obesity.
