About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

How Drug Interferes With Neuronal Cell Function Discovered in York U Autism-Related Study

by Kathy Jones on July 9, 2010 at 11:28 PM
Font : A-A+

 How Drug Interferes With Neuronal Cell Function Discovered in York U Autism-Related Study

The mechanism behind how the drug misoprostol, which has been linked to neurodevelopmental defects associated with autism, interferes with neuronal cell function has been shown in a new study by York University study.

It is an important finding because misoprostol is similar in structure to naturally-occurring prostaglandins, which are the key signaling molecules produced by fatty acids in the brain.

Advertisement

Past clinical studies have shown an association between misoprostol and severe neurodevelopmental defects including autism symptoms. Those studies looked at cases in Brazil in which women misused the drug early in pregnancy in unsuccessful attempts to terminate their pregnancies.

The York study examined mouse neuronal cells to discover how the drug actually interferes at a molecular level with prostaglandins, which are important for development and communication of cells in the brain.
Advertisement

"Early in the first trimester of pregnancy, neuronal cells reach out to communicate with one another," says Dorota Crawford, an assistant professor in the School of Kinesiology & Health Science in York's Faculty of Health. "Our study shows that misoprostol interferes with this process by increasing the level of calcium ions in neuronal extensions, which reduces the number and length of these extensions. It prevents the cells from communicating with each other. If changes in prostaglandin level alter the development or differentiation of cells, it may have a physiological impact."

Crawford and Javaneh Tamiji, who undertook the research for her master's thesis in the Neuroscience Graduate Diploma Program at York, co-authored a study published online in the journal Biochemical and Biophysical Research Communications: "Prostaglandin E2 and misoprostol induce neurite retraction in Neuro-2a cells."

There is no indication that women in Canada are misusing misoprostol to terminate pregnancies, and in fact the drug is used safely for other purposes such as treatment and prevention of gastrointestinal ulcers. However, during early neuronal development the drug misoprostol or other environmental factors such as infections or inflammations, which can also increase the level of prostaglandins, may interfere with normal brain function, says Crawford.

Crawford and Tamiji focused on the drug misoprostol because they had evidence from the clinical studies of the neurotoxic effects of the drug. They used misoprostol and the naturally occurring prostaglandins side by side in their study and found that both compounds produced the same effects on neuronal cell function.

The study shows that misoprostol interferes with the prostaglandin pathway in a dose-dependent manner - in other words, the higher the dose, the greater the problems created.

"What that indicates to us is whether it is infection that will activate it, or whether it is the drug, it will cause the same effect," says Crawford.

Now that it has been shown that misoprostol affects interaction between cells, the next step will be to do animal studies on mice to examine the physiological impacts on particular parts of the brain, she says.

Crawford's lab is one of very few in the world that has adopted a multidisciplinary approach to the study of autism spectrum disorders, using molecular techniques to understand the link between causative biological factors (genes and environment) and the behavioural expression.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Get Involved and Stand Up for Human Rights on Human Rights Day 2022
Coronary Artery Bypass Grafting
Macronutrients Calculator for Weight Loss
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Parkinsons Disease Surgical Treatment Signature Drug Toxicity 

Most Popular on Medindia

Daily Calorie Requirements Loram (2 mg) (Lorazepam) Diaphragmatic Hernia Find a Doctor The Essence of Yoga Blood Donation - Recipients How to Reduce School Bag Weight - Simple Tips Sanatogen Drug Side Effects Calculator Hearing Loss Calculator
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

How Drug Interferes With Neuronal Cell Function Discovered in York U Autism-Related Study Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests