How can the Brain Effectively Place New Memories?

by Bidita Debnath on  December 16, 2017 at 11:52 PM Research News
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Brain gives us awareness of ourselves and of our environment, processing a constant stream of sensory data. Every creative thought, feeling, and plan is developed by our brain.
How can the Brain Effectively Place New Memories?
How can the Brain Effectively Place New Memories?

New UC Berkeley research shows that like swinging a tennis racket during a ball toss to serve an ace, slow and speedy brainwaves during deep sleep must sync up at exactly the right moment to hit the save button on new memories.

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While these brain rhythms, occurring hundreds of times a night, move in perfect lockstep in young adults, findings published in the journal Neuron show that, in old age, slow waves during non-rapid eye movement (NREM) sleep fail to make timely contact with speedy electrical bursts known as "spindles."

"The mistiming prevents older people from being able to effectively hit the save button on new memories, leading to overnight forgetting rather than remembering," said study senior author Matthew Walker, a UC Berkeley professor of neuroscience and psychology and director of the campus's Center for Human Sleep Science.

"As the brain ages, it cannot precisely coordinate these two deep-sleep brain waves," Walker added. "Like a tennis player who is off their game, they're swiping and missing."

In tennis lingo, for example, the slow brainwaves or oscillations represent the ball toss while the spindles symbolize the swing of the racket as it aims to make contact with the ball and serve an ace.

"Timing is everything. Only when the slow waves and spindles come together in a very narrow opportunity time window (approximately one-tenth of a second), can the brain effectively place new memories into its long-term storage," said study lead author Randolph Helfrich, a postdoctoral fellow in neuroscience at UC Berkeley.

Moreover, researchers found that the aging brain's failure to coordinate deep-sleep brainwaves is most likely due to degradation or atrophy of the medial frontal cortex, a key region of the brain's frontal lobe that generates the deep, restorative slumber that we enjoy in our youth.

"The worse the atrophy in this brain region of older adults, the more uncoordinated and poorly timed are their deep-sleep brainwaves," Walker said. "But there is a silver lining: Sleep is now a new target for potential therapeutic intervention."

To amplify slow waves and get them into optimal sync with spindles, researchers plan to apply electrical brain stimulation to the frontal lobe in future experiments.

"By electrically boosting these nighttime brainwaves, we hope to restore some degree of healthy deep sleep in the elderly and those with dementia, and in doing so, salvage aspects of their learning and memory," Walker said.

For the study, researchers compared the overnight memory of 20 healthy adults in their 20s to that of 32 healthy older adults, mostly in their 70s. Before going to bed for a full night's sleep, participants learned and were then tested on 120 word sets.

As they slept, researchers recorded their electrical brain-wave activity using scalp electroencephalography (EEG). The next morning, study participants were tested again on the word pairs, this time while undergoing functional and structural magnetic resonance imaging (fMRI) scans.

The EEG results showed that in older people, the spindles consistently peaked early in the memory-consolidation cycle and missed syncing up with the slow waves.

Moreover, brain imaging showed grey matter atrophy in the medial frontal cortex of older adults, which suggests that deterioration within the frontal lobe prevents deep slow waves from perfectly syncing up with spindles.

Source: Eurekalert

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