About My Health Careers Internship MedBlogs Contact us

Host Genes Aiming at Anti-Viral Drugs and Vaccines Identified

by Nancy Needhima on January 30, 2012 at 10:57 PM
Font : A-A+

Host Genes Aiming at Anti-Viral Drugs and Vaccines Identified

Influenza virus can rapidly metamorphose, complicating the effectiveness of vaccines and anti-viral drugs employed in treating it.

Now, University of Georgia researchers have identified several novel host genes and associated cell pathways that can be targeted with existing drugs to silence virus replication.


The researchers studied RNA interference to determine the host genes influenza uses for virus replication.

All viruses act as parasites by latching onto healthy cells and hijacking the cells' components, essentially turning the cell into a factory that produces copies of the virus. This process begins when influenza binds to sugars found on the surface of host cells in the lung and respiratory tract. Once attached, the virus downloads its genetic information into the nucleus of the cell, and virus replication begins.

"Viruses contain very minimal genetic information and have evolved to parasitize host cell machinery to package and replicate virus cells. Because virus replication is dependent on host cell components, determining the genes needed for this process allows for the development of novel disease intervention strategies that include anti-virals and vaccines," said study co-author Ralph Tripp, a Georgia Research Alliance Eminent Scholar and Chair of Animal Health Vaccine Development in the UGA College of Veterinary Medicine.

"We have the technology today that allows us to target specific genes in human cells and silence those genes to inhibit the production of virus in the cells," he said.

RNA interference, which was first discovered as the mechanism that effects color change in petunia breeding, is now being applied to medical advancements.

Using RNAi silencing technologies, Tripp's lab was able to identify key host cell pathways needed by influenza virus for replication.

"We have a very limited toolbox for treating influenza. There are two medications currently used to treat flu infections, but virus resistance has developed to these drugs. Our studies have identified several novel host genes and associated cell pathways that can be targeted with existing drugs to silence virus replication," Tripp said.

Understanding which genes can be silenced to inhibit growth of viruses opens the medicine cabinet for the repurposing of existing drugs.

Existing anti-viral drugs slow influenza virus replication by preventing the virus from releasing itself from its host cell. These treatments target the virus, which is able to rapidly mutate to avoid drug sensitivity. In contrast, drugs that target host genes work more effectively because host genes rarely change or mutate.

"If we target a host gene, the virus can't adapt," Tripp said.

The influenza virus "may look for other host genes in the same pathway to use, which may be many, but we have identified the majority of preferred genes and can target these genes for silencing."

"Through this research we can repurpose previously approved drugs and apply those to influenza treatments, drastically reducing the time from the laboratory to human medicine," said Victoria Meliopoulos, a UGA graduate student and co-author of the study.

"We can manipulate the cellular microenvironment to increase the viral yield during vaccine manufacturing," she stated.

Meliopoulos said these discoveries could be used to create new anti-viral drugs and develop better vaccines that can be used to treat patients with influenza.

The study has been published in the January issue of the Journal of the Federation of American Societies for Experimental Biology.

Source: ANI

News A-Z
News Category
What's New on Medindia
January is the Thyroid Awareness Month in 2022
Menstrual Disorders
Coffee May Help You Fight Endometrial Cancer
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Drugs Banned in India Vaccination for Children Weaver Syndrome Top 10 Vaccine Myths Debunked 

Recommended Reading
Effectiveness of Inactivated Influenza Vaccine in Children Aged 9 Months to 3 Years
Researchers studied the effectiveness of trivalent inactivated influenza vaccine against ......
Flu Vaccine may be Safely Administered to Children With Egg Allergy: Study
The results of a recent study indicate that flu vaccine containing less than 0.33 μg/ml of egg ...
Swine Flu Or Pig Flu Facts
Is the world in the grip of its first influenza pandemic in forty years? It definitely seems so! ......
Complete Assessment Required for Use of Anti-influenza Drug
Lack of availability of data has interfered with the assessment of the anti-influenza drug ......
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Drugs Banned in India
Several drugs are either banned or withdrawn after introduction in the market....
Top 10 Vaccine Myths Debunked
Childhood vaccination has saved many lives, yet lots more has to be done to increase awareness and e...
Vaccination for Children
Vaccines are biological products that impart immunity to the recipient. Vaccines may be live attenua...
Weaver Syndrome
Weaver syndrome is a genetic disorder in which children show accelerated bone growth, advanced bone ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)