About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Host Cell Promoted by Fungal Surface Protein, Says Research

by Kathy Jones on December 22, 2013 at 4:38 PM
Font : A-A+

 Host Cell Promoted by Fungal Surface Protein, Says Research

Despite current prophylactic strategies, opportunistic infections in individuals on immunosuppressive therapy are a major problem.

While the ability to prevent infection with well-characterized pathogens has improved, infection by less-known microbes have been on the rise. One such example is the increasing occurrence of mucormycosis, a life-threatening infection caused by Mucorales fungi. A defining characteristic of Mucorales is the ability to invade host cells via interaction with glucose-regulated protein 78 (GRP78) on the surface of endothelial cell. In this issue of the Journal of Clinical Investigation, Ashraf Ibrahim and colleagues at the University of California, Los Angeles identified spore coat protein homologues (CotH) on the surface of Mucorales fungi as the ligand for GRP78 and that gene encoding these proteins are unique to Mucorales. Furthermore, loss of CotH in the Mucorales fungi Rhizopus oryzae decreased invasion and virulence. In a companion commentary, J. Andrew Alspaugh of Duke University discusses the potential of targeting CotH proteins for prevention and treatment of mucormycosis.

Advertisement


Source: Eurekalert

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Health Benefits of Sea Buckthorn
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Surgical Treatment 

Recommended Reading
Birth Defects - Infections
Birth defects are abnormalities, which occur before the birth of the baby and can be caused due to ....
Nail Infections Caused by Manicures
It is important to have manicured hands for a chic look, it is more important to have healthy ......
Tapeworm Infections
Tapeworms are a group of parasites that depend on humans for growth and cause intestinal infection ....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use