Apelin, a hormone produced by fat and other tissues, might serve as a promising target for managing insulin resistance and type 2 diabetes, according to a new study.
Usually, insulin makes it possible to store blood sugar in the form of glucose in the liver or adipose tissue (fat). The stored glucose is needed for the satisfactory function of the heart, brain and so on according to the body's demands.
Insulin
This medication is a hormone produced in the pancreas, prescribed for type 1 diabetes. It is also used for type 2 diabetes.
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Many times, the mechanism gets disrupted either because insulin is no longer produced (type 1 diabetes), or because the receptors located on the surface of liver cells are desensitized (type II diabetes). Thus, the cell becomes incapable of assimilating glucose.
Such a dysfunction causes a rise in blood sugar levels leading to the onset of numerous complications.
In the new study, led by Philippe Valet, researchers have found that our cells are equipped with a second pathway for the assimilation of glucose, which involves "apelin".
![Top Ten Facts About Diabetes]( "Top Ten Facts About Diabetes")
Diabetes or diabetes mellitus, is an endocrine and metabolic disorder characterized by high blood sugar levels (hyperglycemia) over a prolonged period of time.
The protein is not only a "key" that is different from insulin, but it also passes through a different receptor or "doorway".
The new discovery may prove to be effective mainly in case of type II diabetics where the receptor or doorway is impaired rather than the key.
The findings make it possible to short-circuit this mechanism and achieve sugar assimilation by a completely different pathway from that mediated by insulin.
Usually, the second pathway is only responsible for a small proportion of sugar integration.
But, the tests in mice have revealed that in case of type II diabetes, activation of apelin mediated route improves the regulation of blood sugar levels.
"We now have to check the action of this protein in man. In parallel, we are developing a synthetic molecule that may be used if the tests in man are positive," concluded Valet.
Source: ANI
SK
In the new study, led by Philippe Valet, researchers have found that our cells are equipped with a second pathway for the assimilation of glucose, which involves "apelin".
Top Ten Facts About Diabetes
Diabetes or diabetes mellitus, is an endocrine and metabolic disorder characterized by high blood sugar levels (hyperglycemia) over a prolonged period of time.
Advertisement
The protein is not only a "key" that is different from insulin, but it also passes through a different receptor or "doorway".
The new discovery may prove to be effective mainly in case of type II diabetics where the receptor or doorway is impaired rather than the key.
The findings make it possible to short-circuit this mechanism and achieve sugar assimilation by a completely different pathway from that mediated by insulin.
Usually, the second pathway is only responsible for a small proportion of sugar integration.
But, the tests in mice have revealed that in case of type II diabetes, activation of apelin mediated route improves the regulation of blood sugar levels.
"We now have to check the action of this protein in man. In parallel, we are developing a synthetic molecule that may be used if the tests in man are positive," concluded Valet.
Source: ANI
SK
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