But the fight against pain, discomfort and a constant urge to urinate has taken a step forward with scientists identifying how the immune systems defence against bladder infection causes nerves to magnify the sensations felt by patients.
Clinical Pharmacology Research Fellow & Head of Bladder Research, Dr Luke Grundy, says understanding how nerves in the bladder transmit different sensations to the brain could potentially help limit bladder dysfunction in overactive bladder patients.
"We believe that chronic pain and bladder dysfunction are a failure of these nerves to reset after inflammation, so by understanding how these nerves function with a UTI and what causes them to become more sensitive over time, we can develop effective treatments."
"This is important, as many people diagnosed with an overactive bladder, a disorder that is currently considered to have no specific cause, have a history of urinary tract infections, and have been shown to have persistent low levels of UTI. This may lead to enhanced patient diagnosis and alternative treatment options for those suffering with an overactive bladder."
With the number of antibiotic resistant UTI's growing globally each year, many can no longer be treated with common antibiotics despite the fact one in every two women will develop a UTI in their lifetime.
"Our study provides a new understanding of why some overactive bladder patients do not respond to traditional medications and continue to suffer in silence, and opens the door for the development of more specific and effective treatments in the future".
Chaired by two of Flinders University's renowned gut researchers, Professor Nick Spencer and Professor Stuart Brierley, a week long conference will delve into the latest gut / brain breakthroughs at the annual meeting of the Federation of Neurogastroenterology and Motility, from 24 to 28 March 2020.
The 4th Meeting of the Federation of NeuroGastroenterology and Motility is hosted by the Australasian NeuroGastroenterology and Motility Association Inc, the American NeuroGastroenterology and Motility Society, the Asian NeuroGastroenterology and Motility Association, the European Society of Neurogastroenterology and Motility, and the Latin-American Society of Neurogastroenterology.
Source: Eurekalert
