About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Hope for Cancer Cure After Stem Cell Breakthrough

by Rajashri on October 14, 2008 at 3:36 PM
Font : A-A+

 Hope for Cancer Cure After Stem Cell Breakthrough

In a major breakthrough, researchers have succeeded in triggering a cancer-like response by disrupting a natural bioelectrical mechanism within frog embryonic stem cells.

Scientists from The Forsyth Institute, working with collaborators at Tufts and Tuebingen Universities, said that they could trigger responses like increased cell growth, change in cell shape, and invasion of the major body organs.

Advertisement

The researchers said that their study suggested that electrical signals were a powerful control mechanism that could be used to modulate cell behaviour.

Dr. Michael Levin, the Director of the Forsyth Center for Regenerative and Developmental Biology, revealed that the team had identified a new function for a potassium (KCNQ1) channel, mutations of which are known to be involved in human genetic diseases such as Romano-Ward and Jervell-Lange-Nielsen syndromes.
Advertisement

He said that interrupting the flow of potassium through KCNQ1 in parts of the Xenopus frog embryo resulted in a striking alteration of the behaviour of one type of embryonic stem cell: the pigment cell lineage of the neural crest.

When mutated, the pigment cells over-proliferated, spread out, and became highly invasive of blood vessels, liver, heart, and neural tube, leading to a deeply hyper-pigmented tadpole.

The observations made during the study showed that key properties of embryonic stem cells could be controlled through bioelectrical signals, and that potassium flows could be an important aspect of cellular environment, which is known to regulate both cancer and stem cells.

"In regenerative medicine, a key goal is to control the number, position, and type of cells. This research is especially exciting because it shows the importance of electrical signals for changing cell behaviour, identifies a new role in developmental and cell biology for the KCNQ1 ion channel, and strengthens the link between stem cells and tumour cells," said the paper's first author, Junji Dr. Morokuma.

Dr. Doug Blackiston, who jointly wrote the research paper, added: "In the future, this work may lead to a greater understanding of the causes of cancer and ways to potentially halt its metastasis, as well as suggesting new techniques by which stem cells may be controlled in biomedical applications."

An article on the research has been published in the journal Proceedings of the National Academy of Sciences.

Source: ANI
RAS/SK
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
Long-Term Glycemic Control - A Better Measure of COVID-19 Severity
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Stem Cells - Cord Blood Stem Cells - Fundamentals Cancer and Homeopathy Genetics and Stem Cells Cancer Facts Cancer Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant Immune Checkpoint Inhibitors for Cancer Treatment Non-Communicable Diseases 

Recommended Reading
Women and Cancer
Cancer is one of the frequently talked about and most feared disease that falls under the genre of ....
Liver Cancer - Animation
Liver is the largest organ inside the human body. It performs 500 different functions and processes ...
Common Lifestyle Habits that Cause Diseases
Cigarette smoking, unhealthy diets, overuse of alcohol, and physical inactivity are some of the most...
Health Benefits of Dandelion Plant
What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health benefits. ...
Immune Checkpoint Inhibitors for Cancer Treatment
Immune checkpoint inhibitors are promising drugs to treat a variety of cancers and the FDA has appro...
Non-Communicable Diseases
Non-Communicable Diseases (NCDs) are a group of chronic non-infectious diseases which include Cardio...
Stem Cells - Fundamentals
Encyclopedia section of medindia gives general info about Stem Cells...
Stem Cells - Cord Blood
Encyclopedia section of medindia gives general info about Cord Blood...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use