Published in the European Journal of Clinical Microbiological Infectious Diseases, the research paper points out that this exciting new treatment has been around since the dawn of history-honey was first used as a first aid treatment four thousand years ago in Ancient Egypt.
Leptospermum honey has been shown to possess unique plant derived components that make it an ideal wound dressing, including novel antimicrobial and immune-modulatory compounds.
What is also key is that all these benefits exist without any toxicity to healthy tissue.
"There is an urgent need for new, effective agents in topical wound care, and selected honeys show potential in this regard," the report states.
The paper also describes how medical-grade honey might be a strong combatant against antibiotic resistant pathogens, such as MRSA and vancomycin-resistant strains (VRS).
"Staphylococcus aureus is one of the most commonly acquired pathogens in both the community and the hospital settings, and it is particularly problematic in skin and wound infections. The emergence of methicillin resistant S. aureus (MRSA), and, more recently, vancomycin-resistant strains, has seriously compromised treatment options," the report states.
"Multi-drug resistance limits treatment options and results in the use of more expensive or more toxic drugs, with corresponding increases in patient morbidity and mortality. . . The current issues surrounding antibiotic resistance, and a growing body of evidence supporting the use of honey as a dressing for a wide range of wounds, has increased interest in its use in the clinic," it adds.
The paper also demonstrates that use of this kind of honey at sub-lethal levels-too low to kill bacteria-does not induce resistance, something which is unusual because this is precisely what causes resistant strains to form after sub-lethal antibiotic / antimicrobial concentration exposure.
It further reveals that a gene expression analysis, carried out to determine whether the honey's effect was different than that of traditional antibiotics, led to the conclusion: "When compared to the published data on the effects of various antibiotics on the gene expression of E. coli, active Leptospermum honey produced a unique expression signature, suggesting that it works by a different mode of action to the other inhibitors."
"The data presented here argue for a greater use of medicinal-grade honey in wound care, particularly where antibiotic resistance is an issue," the paper concludes.
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