Higher Risk of Heart Disease in Women With Polycystic Ovary Syndrome

Heightened risk of developing heart disease, diabetes, reproductive disorders and cancer of uterus lining is found in women diagnosed with polycystic ovary syndrome.

Heightened risk of developing heart disease, diabetes, mental health conditions, reproductive disorders and cancer of uterus lining is found in women diagnosed with polycystic ovary syndrome than healthy women, revealed a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism. The PCOS is the most common hormone disorder in women of reproductive age.

Polycystic ovary syndrome (PCOS) is a leading cause of infertility. The condition occurs when a woman's body produces slightly higher amounts of testosterone and other androgen hormones than normal. The resulting hormone imbalance can cause irregular or absent menstrual periods, infertility, weight gain, acne, excess hair on the face and body, or thinning hair on the scalp. As many as 5 million women nationwide have PCOS, according to the U.S. Department of Health and Human Services' Office of Women's Health.

Polycystic Ovarian Syndrome - Overview
Polycystic ovarian syndrome is the most common hormonal disorder among women of reproductive age and can cause infertility.

"PCOS has profound implications for a women's reproductive health as well as her long-term risk of chronic illness," said one of the study's authors, Roger Hart, MD, MRCOG, FRANZCOG, CREI, of the University of Western Australia and Fertility Specialists of Western Australia, both in Perth, Australia. "Our study indicates women who have PCOS have twice as many hospital admissions as women without the condition. Additional health care resources should be directed to address the risks facing this population."

The population-based retrospective cohort study examined health records for 2,566 women ages 15 and older who were diagnosed with PCOS during a hospital visit in Western Australia between 1997 and 2011. This population's records were compared to hospitalization records for 25,660 women of similar ages, who were identified using voter registration records. Researchers tracked the participants' hospitalization records until the women reached a median age of 35.8 years.

Researchers analyzing the data found women who were diagnosed with PCOS were more likely to be hospitalized for reasons unrelated to reproductive health or injury than their counterparts. Women who had PCOS were more likely to have miscarriages, ectopic pregnancies or other gynecological conditions such as irregular menstrual periods and endometriosis. Women who had PCOS also had a higher rate of endometrial cancer, or cancer of the lining of the uterus.

Link Between Endometriosis and Ovarian Cancer
Endometriosis is associated with three specific invasive ovarian cancers - low-grade serous, endometrioid, and clear-cell ovarian cancer, according to a recent study.

Women diagnosed with PCOS were hospitalized more often for mental health disorders such as depression, stress and anxiety than other study participants. A PCOS diagnosis also was associated with a higher risk of late onset diabetes, high blood pressure, heart disease, asthma and musculoskeletal disorders.

"We found women who have PCOS are particularly prone to developing metabolic and cardiovascular disease," Hart said. "Since only 25 percent of the women we studied were older than 40, we anticipate the rate of diagnosis would rise as these women continue to age."