Infants born to pregnant women who had higher levels of vitamin B had lower risk of developing eczema at age 12 months, according to a latest study.
The study conducted by researchers of the Medical Research Council Lifecourse Epidemiology Unit at the University of Southampton, is the fist of its kind that links maternal serum levels of nicotinamide, a naturally occurring vitamin and related metabolites to the risk of atopic eczema in the child.
Nicotinamide is a form of vitamin B3. Its level is maintained through intake of foods such as fish, meat, chicken, mushrooms, nuts and coffee as well as tryptophan, an amino acid found in most proteins. Nicotinamide and related nutrients are important for the body's immune responses and energy metabolism.
Dr Sarah El-Heis, the study's lead researcher from the University of Southampton, comments "Nicotinamide cream has been used in the treatment of eczema but the link between the mother's levels of nicotinamide during pregnancy and the offspring's risk of atopic eczema has not been previously studied. The findings point to potentially modifiable influences on this common and distressing condition."
For the study, researchers assessed the amount of nicotinamide and related tryptophan metabolites during pregnancy in 497 women that took part in the Southampton Women's Survey. The rates of eczema in their children at ages 6 and 12 months was studied.
Results showed that offspring of mothers with higher levels of nicotinamide had a 30% lower chance of developing atopic eczema at 12 months. There was an even stronger association with higher levels of anthranilic acid, a tryptophan metabolite.
Nicotinamide can improve the overall structure, moisture and elasticity of skin and therefore could potentially alter the disease processes associated with eczema, the researchers say. The study showed a gradual association between higher maternal nicotinamide and anthranilic acid levels and a lower risk of atopic eczema, suggesting that the development of eczema is not simply prevented by the presence of these nutrients.
Professor Keith Godfrey, Director of the NIHR Southampton Biomedical Research Centre in Nutrition, added "More research is needed to investigate this interesting association, but the findings are further evidence of the potential benefits of eating a healthy balanced diet during pregnancy."