Too much fat in your diet can lead to life-threatening liver disease, reports a new study. The findings of the study are published in the journal Hepatology.
A new study by Keck School of Medicine of USC researchers shows there's yet another reason to avoid a high fat, high cholesterol diet: It can trigger changes in the immune system that lead to a serious form of non-alcoholic fatty liver disease (NAFLD) known as non-alcoholic steatohepatitis (NASH).
High Consumption of Red Meat may Cause Non-alcoholic Fatty Liver Disease (NAFLD)
NAFLD (non-alcoholic fatty liver disease) and insulin resistance may be caused due to high consumption of red and processed meat.
Advertisement
‘Eating a diet high in fat and cholesterol can trigger changes in the immune system that lead to a serious form of non-alcoholic fatty liver disease (NAFLD) known as non-alcoholic steatohepatitis (NASH).’
Read More..
Tweet it Now
Read More..
NAFLD is one of the most common causes of liver disease in the United States, and an estimated 20 percent of people with NAFLD have NASH. NASH can eventually progress to cirrhosis or liver cancer, especially in those with obesity or Type 2 diabetes. Patients with NAFLD are also at an increased risk of cardiovascular disease.
"Despite its increasing prevalence and burden to the health care system, there are currently no U.S. Food and Drug Administration-approved therapies for non-alcoholic fatty liver disease," says the study's corresponding author, Hugo Rosen, MD, professor, and chair of the Department of Medicine at the Keck School.
![New Hope for Treating Non-Alcoholic Fatty Liver Disease]( "New Hope for Treating Non-Alcoholic Fatty Liver Disease")
Researchers have discovered a new pathway in the liver that opens the door to treat non-alcoholic fatty liver disease.
"There's an urgent need to better understand the causes of non-alcoholic fatty liver disease progression so that successful therapeutics can be designed and brought into clinical practice."
The study illuminates how a toxic combination of dietary fat and cholesterol impacts the behavior of macrophages, a type of white blood cell, in the liver. Using a mouse model, the study details the cascade of events in the immune system that eventually leads to the type of liver inflammation and scarring that is commonly seen in patients with NASH.
After feeding mice diets with varying levels of fat and cholesterol, the team found that the combination of both had a synergistically detrimental action on the genes regulating liver inflammation and scarring. Oxidized low-density lipoprotein cholesterol, in particular, directly altered gene expression in both human and mouse macrophages associated with inflammation and scar formation.
The group also identified a novel type of reparative macrophage that counteracts the inflammation.
"Not only does this study define how fat and cholesterol shape the progression of liver inflammation and scarring, but it also identifies potential pathways that can be targeted for future therapies. That could bring us closer to finding a treatment for a disease that impacts millions of lives around the world," he says.
"Here at the Keck School, we are committed to building a cutting-edge research and clinical program that identifies mechanisms of NASH, non-invasive approaches for diagnosis and risk stratification, and clinical implementation of novel strategies for treatment."
Source: Eurekalert
New Hope for Treating Non-Alcoholic Fatty Liver Disease
Researchers have discovered a new pathway in the liver that opens the door to treat non-alcoholic fatty liver disease.
Advertisement
"There's an urgent need to better understand the causes of non-alcoholic fatty liver disease progression so that successful therapeutics can be designed and brought into clinical practice."
The study illuminates how a toxic combination of dietary fat and cholesterol impacts the behavior of macrophages, a type of white blood cell, in the liver. Using a mouse model, the study details the cascade of events in the immune system that eventually leads to the type of liver inflammation and scarring that is commonly seen in patients with NASH.
After feeding mice diets with varying levels of fat and cholesterol, the team found that the combination of both had a synergistically detrimental action on the genes regulating liver inflammation and scarring. Oxidized low-density lipoprotein cholesterol, in particular, directly altered gene expression in both human and mouse macrophages associated with inflammation and scar formation.
The group also identified a novel type of reparative macrophage that counteracts the inflammation.
"Not only does this study define how fat and cholesterol shape the progression of liver inflammation and scarring, but it also identifies potential pathways that can be targeted for future therapies. That could bring us closer to finding a treatment for a disease that impacts millions of lives around the world," he says.
"Here at the Keck School, we are committed to building a cutting-edge research and clinical program that identifies mechanisms of NASH, non-invasive approaches for diagnosis and risk stratification, and clinical implementation of novel strategies for treatment."
Source: Eurekalert
Obese Children Should be Screened for Non-Alcoholic Fatty Liver Disease
A screening test for non-alcoholic fatty liver disease has been recommended for all obese children aged 9-11 years.
Advertisement
 Top 5 Foods to Fight Non-alcoholic Fatty Liver DiseaseTop 5 natural ways to fight non-alcoholic fatty liver disease have been revealed by health expert. More than a million new patients are diagnosed with liver cirrhosis every year globally. | Advertisement
|
Advertisement
Recommended Readings
Latest Diet & Nutrition News
The nutritional profile of American diet can be significantly improved by substituting small amounts of pulses for refined grains and common protein sources.
Lowering the intake of isoleucine in diet can extend lifespan, promote a slim body, anti-aging properties, and reduce cancer and prostate health issues.
Keep Thanksgiving leftovers safe: Refrigerate promptly, use airtight containers, label and date, and reheat properly.
Poor nutrition raises the risk of type 2 diabetes, and mental issues like anxiety and depression. Nutrition interventions aid in managing these health issues.
Micronutrient deficiencies may play a crucial role in the worldwide surge of antibiotic resistance.