'High Fat' Diet may Now Help Fight Obesity

A diet high in a particular kind of fat may actually be helpful in increasing metabolism, a new research has found

A diet high in a particular kind of fat may actually be helpful in increasing metabolism, a new research has found.

After studying genetically modified mice, the discovery by Texas Tech University nutrition scientists could lead to supplements and a diet regime that will increase metabolism and decrease muscle fatigue in humans.

Obesity risk for immobilized adults
Data from a national survey of more than 149,000 Americans including 23,000 participants with one or more forms of disability showed that 25% of

Chad Paton, an assistant professor of nutritional biochemistry in the Department of Nutrition, Hospitality and Retailing, said that he and his colleagues were curious why skeletal muscles of obese people contained a certain type of enzyme that breaks down saturated fats.

To test what that enzyme did, Paton's lab and colleagues from the University of Wisconsin - Madison genetically modified mice so that their muscles would constantly produce the enzyme.

"We used a transgenic mouse model, and we took the gene that makes the enzyme that's not normally expressed and took away it's regulation to make it active all the time," Paton said.

Simple Blood Test to Help Beat Obesity, Coming Soon
A simple blood test could help beat obesity as researchers have found what makes us gorge on junk food.

"What we found in those animals is they had a hypermetabolic rate compared to the wild mice, increased energy consumption and greatly increased these animals' exercise capacity," he said.

The enzyme, called SCD1, converts saturated fat into monounsaturated fat, which is easier to metabolize.

Lean Protein Could Be Key to Obesity Drugs
A protein that lets mice eat more but weigh less could prove the magic ingredient for diet drugs of the future.British scientists from drug giant

The liver will produce this enzyme depending on the fat content of the food consumed, he said.

Fatty adipose tissue produces it all the time as a way of regulating itself.

Only in heavily exercised muscle tissue or in the case of obesity does skeletal muscle produce the enzyme, he said.

After looking at skeletal muscles of the genetically modified mice compared to that of the wild mice, Paton and his team discovered higher levels of polyunsaturated fats, particularly linoleic acid, gotten only through diet.

Higher levels of linoleic acid could only mean one thing - the modified mice were eating more food. But Paton's team found that the modified mice weighed less than the wild mice. On top of that, their ability to exercise increased.

The research is published in the peer reviewed journal, The Journal of Lipid Research.

Source-ANI