The immune system can fight almost any infection by creating customised antibodies for the particular infection which is influenced by genes.

‘A set of epigenetic marks and proteins behave like genetic switches and together control which genes contribute to making antibodies.’

The immune system can fight almost any infection by creating customised antibodies. Each antibody is made by combining a few genes from a large selection of possible components in a process called V(D)J recombination. Like building blocks, each combination of genes creates a unique antibody. 




Some of these genetic building blocks are much more likely to be used by the immune system than others, and it is not clear why. This new study uses mice to identify for the first time a set of epigenetic marks and proteins, which behave like genetic switches and that together control which genes contribute to making antibodies.
The best antibodies are very precise in locking on to the causes of a particular illness. By combining genes in many different ways to make different antibodies, the immune system creates antibodies with the precision needed to identify and fight any possible infection.
Some people have genetic conditions that mean their immune system can not produce a large enough variety of antibodies, so they are less able to fight diseases. The immune system also weakens as we age. In both cases, changes to this newly discovered control mechanism could be partly responsible for these weaknesses.
The first author on the paper and postdoctoral researcher at the Babraham Institute, Dr Louise Matheson, said: "Our bodies are able to produce millions of different antibodies from just a few genes using V(D)J recombination, so it's an incredibly complex system. We wanted to understand how this process is controlled as well as which epigenetic marks and proteins are involved. By understanding these systems we can learn how to better control the immune system and how to help it fight infections."
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The scientist that led the research, Dr Anne Corcoran, Group Leader at the Babraham Institute, said: "We have discovered some of the key factors that switch on the genes that make antibodies. This is a valuable insight into how the immune system protects our bodies, and what may be at fault when the immune system is weakened. This will ultimately help us to design diagnostic tests for people affected by recurrent infections and to devise therapies to boost the body's response to infection."
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Source-Eurekalert